Carmelo PUGLIA

Professore associato di Farmaceutico tecnologico applicativo [CHIM/09]
Ufficio: piano terra - Dipartimento di Scienze del Farmaco
Email: capuglia@unict.it
Telefono: ++39 0957384206
Orario di ricevimento: da concordare tramite mail


Il Prof. CARMELO PUGLIA è Professore Associato presso il Dipartimento di Scienze del Farmaco dell'Università degli Studi di Catania, dove ricopre l’incarico di docente di Tecnologia, Socioeconomia e Legislazione Farmaceutica con laboratorio (Corso M-Z) per il Corso di Laurea in Chimica e Tecnologia Farmaceutiche e di Legislazione dei Prodotti Erboristici e della Salute per il Corso di Laurea in Scienze Farmaceutiche Applicate (SFA). E' inoltre docente di “Classificazione ed Impieghi dei Dispositivi Medici e Diagnostici” per la Scuola di Specializzazione in Farmacia Ospedaliera dell'Università di Catania. Il Prof. Puglia è autore e coautore di circa 80 pubblicazioni scientifiche e di circa 30 comunicazioni a congressi (orali e posters). Le principali tematiche di ricerca riguardano: veicolazione di farmaci mediante sistemi micro e nanoparticellari allo scopo di aumentare la biodisponibilità e la stabilità di attivi farmaceutici; valutazione del grado di assorbimento percutaneo in vitro ed in vivo di attivi contenuti in formulazioni destinate all’applicazione topica, sia con finalità cosmetica o dermatologica che sistemica (sistemi transdermici); formulazione e valutazione di efficacia di prodotti cosmetici mediante studi di assorbimento percutaneo e di spettrofotometria di riflettanza.

  1. F.Bonina, T.Barbuzzi, C.Puglia, I.Muzzalupo, N.Uccella, A.Russo. Attività antiradicalica e fotoprotettiva “in vivo” dell’oleuropeina e dell’idrossitirosolo. Cosm Technol. 1999 2[3]: 18-22.
  2. F.Bonina, C.Puglia, A.Tomaino, A.Saija, N.Mulinacci, A.Romani, F.Vincieri. In vitro antioxidant and in vivo photoprotective effect of three lyophilized extracts of sedum telephium L. leaves. J.Pharm.Pharmacol. 2000, 52: 1279-1285.
  3. F.Bernacchi, C.Puglia, U.Citernesi, F.Bonina. Efficacy evaluation of sun products formulated with radical-scavengers in liposome complexes. Sofw 2001, 127: 30-36.
  4. F.P. Bonina, C.Puglia, T.Barbuzzi, P. de Caprariis, F. Palagiano, M.G. Rimoli, A.Saija. In vitro and in vivo evaluation of polyoxyethylene esters as dermal prodrugs of ketoprofen, naproxen and diclofenac. Eur.J.Pharm.Sci.2001 14: 123-134.
  5. C.Puglia, F.Bonina, G.Trapani, M.Franco, M.Ricci, Evaluation of in vitro percutaneous absorption of lorazepam and clonazepam from hydro-alcholic gel formulations. Int.J.Pharm. 2001 228: 79-87.
  6. F.Bonina, C.Puglia, D.Ventura, M.Fanelli, Sospensioni minerali: attività radical scavenging in vivo. Cosm Technol. 2001 4[6]: 23-26.
  7. R. Aquino, S. Morelli, A.Tomaino, M. Pellegrino, A. Saija,  L.Grumetto, C. Puglia, D.Ventura, F.Bonina. Biophenolic content, antioxidant and photoprotective activity of a crude extract of Culcitium reflexum H.B.K. leaves. J.Ethnopharm. 2002, 79 [2]: 183-191.
  8. F.P.Bonina, C.Leotta, G.Scalia, C.Puglia, D.Trombetta, G. Tringali, A. M. Roccazzello, P. Rapisarda, A. Saija. Evaluation of oxidative stress in diabetic patients after supplementation with a standardised red orange extract. Diab.Nutr.Metab. 2002, 15 [1]: 14-9.
  9. F.Bonina, C.Puglia, A.Saija, D.Trombetta, A.Vanella, A.Russo, P.Rapisarda, U.Cornelli, G.Trincali, E.Insirello, M.Ferro. Proprietà salutistiche dell’estratto di arance rosse di Sicilia: Un elisir dell’Etna. Integr. Nutr. 2002,  5(4) 7-15.
  10. F.P.Bonina, M.G.Rimoli, L.Avallone, F.Barbato, M.Amato, C.Puglia, M.Ricci, P.de Caprariis. New oligoethylene ester derivatives of 5-iodo-2’-deoxyuridine as dermal prodrugs: synthesis, physicochemical properties and skin permeation studies. J.Pharm.Sci. 2002, 91 [1]: 171-179.
  11. F.Bonina, C.Puglia, M.G. Rimoli, L.Avallone, E.Abignente, G.Boatto, M.Nieddu, R.Meli, M.Amorena, P.de Caprariis. Synthesis, in vitro chemical and enzymatic stability of glycosyl 3'-azido-3'- deoxythymidine derivatives as potential anti-HIV agents. Eur.J.Pharm.Sci. 2002, 16 [3]: 167-174.
  12. F.Bonina, C.Puglia, N.A. Santagati, A. Saija, A. Tomaino, B.Tita. Oligoethylene ester derivatives of ketoprofen, naproxen and diclofenac as oral prodrugs: a pharmacological evaluation. Pharmazie. 2002, 56: 552-555.
  13. F.Bonina, C.Puglia, D.Trombetta, M. C. Dragani, M. M.Gentile, G.Calvenna: Vehicle effects on in vitro skin permeation of thiocolchicoside. Pharmazie. 2002, 57: 750-752.
  14. F.Bonina, C.Puglia, D.Ventura, R. Aquino, S.Tortora, A.Sacchi, A.Saija, A.Tomaino, M.L.Pellegrino and P. de Caprariis. In vitro antioxidant and in vivo photoprotective effects of a lyophilised extract of Capparis spinosa L. buds. J.Cosmet. Sci., 2002, 53, 321-335.
  15. F.P.Bonina, C.Puglia, D.Ventura, N.A. Santagati, A.Saija and D. Trombetta. 1-Ethyl and 1-Propylazacycloalkan-2-one Ester Prodrugs of Ketoprofen: Synthesis, chemical stability, enzymatic hydrolysis, anti-inflammatory activity, and gastrointestinal toxicity. Arzneim.-forsch./Drug Res. 2002, 52, 884-889.
  16. F.Bonina, N.A. Santagati and C.Puglia. Ketoprofen 1-Alkylazacycloalkan-2-one Esters as Dermal Prodrugs: In Vivo and In Vitro Evaluations. Drug.Dev.Ind.Pharm., 2003, 29(2), 181-190.
  17. F.Bonina, C.Puglia, C.Di Giovanni, A.Saija, A.Tomaino, B.Tita, F.Vitali, C.Pennisi. Effetto salutistico di un nuovo estratto di uva rossa. Erboristeria Domani., 2003, 273, 80-86.
  18. F.Bonina, C.Puglia, M.G.Rimoli, D.Melisi, G.Boatto, M. Nieddu, A.Calignano, G. La Rana, P. de Caprariis. Glycosyl derivatives of dopamine and L-dopa as anti-Parkinson prodrugs: synthesis, pharmacological activity and in vitro stability studies. J.Drug.Targ., 2003, 11(1), 25-36.
  19. C. Puglia, D. Trombetta, V. Venuti, A. Saija, F. Bonina. Evaluation of in-vivo topical anti-inflammatory activity of indometacin from liposomal vesicles. J. Pharm. Pharmacol., 2004, 56 (10) 1225-1232.
  20. M.Ricci, C.Puglia, F. Bonina, C.Di Giovanni, S.Giovagnoli and C.Rossi Evaluation of indomethacin percutaneous absorption from nanostructured lipid carriers (NLC): in vitro and in vivo studies. J.Pharm.Sci, 2005, 94(5), 1149-1159.
  21. C. Puglia, S. Tropea, L. Rizza, N. A. Santagati and F. Bonina In vitro percutaneous absorption studies and in vivo evaluation of anti-inflammatory activity of essential fatty acids (EFA) from fish oil extracts. Int.J.Pharm. 2005, 299 (1-2), 41-48.
  22. D. Trombetta, F.Occhiuto, D. Perri, C. Puglia, N.A. Santagati, A.De Pasquale, A.Saija, F.Bonina Antiallergic and antihistaminic effect of two extracts of Capparis spinosa L. flowering buds. Phytoter.Res. 2005, 19(1), 29-33.
  23. AM. Panico,V. Cardile, F. Garufi, C. Puglia, F. Bonina, G. Ronsisvalle Protective effect of Capparis spinosa on chondrocytes. Life Sci., 2005, 77 (20), 2479-2488.
  24. F.P. Bonina, C. Puglia, F. Cimino, D. Trombetta, G. Tringali, A. Roccazzello, E. Inzirello, P. Rapisarda, A. Saija Oxidative stress in handball players: effect of supplementation with a red orange extract. Nutr.Res. 2005, 25 (10), 917-924.
  25. C. Puglia, E. Esposito, E. Menegatti, C. Nastruzzi, L. Rizza, R.Cortesi and F. Bonina Effect of charge and lipid concentration on in vivo percutaneous absorption of methyl nicotinate from liposomal vesicles J. Pharm. Pharmacol., 2005, 57(9), 1169-1176.
  26. F. Castelli, C. Puglia, M.G. Sarpietro, L. Rizza and F. Bonina Characterization of indomethacin loaded lipid nanoparticles by differential scanning calorimetry Int.J.Pharm. 2005, 304 (1-2), 231-238.
  27. E. Esposito, R. Cortesi, M.Drechsler, L. Paccamiccio, P. Mariani, C. Contado, E. Stellin, E. Menegatti, F. Bonina, and C. Puglia Cubosome dispersions as delivery systems for percutaneous administration of indomethacin. Pharm.Res. 2005,  22(12),  2163-2173.
  28. F. Bonina, C. Puglia, M. Avogadro, E. Baranelli, G. Cravotto The Topical Protective Effect of Soybean-Germ Oil against UVB-Induced Cutaneous Erythema: an in vivo Evaluation. Arch. Pharm. (Weinheim) 2005, 338(12), 598-601.
  29. C. Puglia, C. Ostacolo, A. Sacchi, S. Laneri and F. Bonina In vitro and in vivo evaluation of oligoethylene esters as dermal prodrugs of 18-β-glycyrrhetic acid. J. Pharm. Pharmacol., 2006, 58(3) 311-319.
  30. D.Trombetta, C. Puglia, D.Perri, A. Licata, S. Pergolizzi, E.R. Lauriano, A. De Pasquale, A. Saija, F.P. Bonina. Effect of polysaccharides from Opuntia ficus-indica (L.) cladodes on the healing of dermal wounds in the rat. Phytomed. 2006, 13(5), 352-358.
  31. AM. Panico, V. Cardile, S. Avondo, F. Garufi, B. Gentile, C. Puglia, F. Bonina, N.A. Santagati, G. Ronsisvalle. The in vitro effect of a lyophilized extract of wine obtained from Jacquez grapes on human chondrocytes. Phytomed. 2006, 13(7), 522-526.
  32. C. Puglia, N.A.Santagati, F. Bonina, D. Trombetta, M. Cristani, A. Speciale, A. Saija. Protective effect of Mediterranean fish oil extracts on heat-induced denaturation of albumin J. Pharm. Pharmacol., 2006, 58, 1411-1413.
  33. C. Puglia, R. Filosa, A. Peduto, P. de Caprariis, L. Rizza, F. Bonina and P. Blasi. Evaluation of alternative strategies to optimize ketorolac transdermal delivery. AAPS PharmSciTech., 2006, 7 (3) article 64, E1-E9.
  34. AM. Panico, V. Cardile, F. Garufi, C. Puglia, F. Bonina, S. Ronsisvalle, Effect of hyaluronic acid and polysaccharides from Opuntia ficus indica (L) cladodes on the metabolism of human chondrocyte cultures. J.Ethnopharm., 2007, 111, 315-321.
  35. F.P.Bonina, M.L. Giannossi, L.Medici, C.Puglia, V.Summa, F.Tateo Adsorption of salicylic acid on bentonite and kaolin and release experiments. Appl.Clay Sci. 2007, 36, 77-85.
  36. C. Puglia, R. Filosa, A. Peduto, P. de Caprariis, G. Boatto, M. Nieddu, N.A.Santagati and F. Bonina Synthesis, physicochemical properties and in vitro permeation studies of new ketorolac ester derivatives.  Curr. Drug. Deliv. 2007, 4(3), 205-210.
  37. C. Puglia and F. Bonina, Effect of PUFAs and some conventional penetration enhancers on transdermal delivery of atenolol. Drug Del., 2008, 15, 107-112.
  38. C. Puglia, P. Blasi, L. Rizza, A.Schoubben, M.Ricci, F. Bonina, C. Rossi, Lipid nanoparticles for prolonged topical delivery: an in vitro and in vivo investigation. Int.J.Pharm. 2008, 357, 295-304.
  39. C. Puglia and F. Bonina, In vivo spectrophotometric evaluation of skin barrier recovery after topical application of soybean phytosterols.  J.Cosm.Sci. 2008, 59, 217-224.
  40. F. P. Bonina, M. L. Giannossi, L. Medici, C. Puglia, V. Summa, F.Tateo, Diclofenac-bearing hydrotalcite: in vitro and in vivo release experiments. Appl.Clay Sci. 2008, 41, 165–171.
  41. V. Cardile, G. Frasca, L. Rizza, F. Bonina, C. Puglia, A. Barge, N. Chiambretti, G. Cravotto, Improved adhesion to mucosal cells of water-soluble chitosan tetraalkylammonium salts. Int.J.Pharm. 2008, 362, 88–92.
  42. F.P. Bonina, M. Marangolo, C. Puglia, F. Cimino, D. Trombetta, G. Tringali, A. Roccazzello, E. Inzirello, P. Rapisarda, A. Saija. Protective effects of a standardized red orange extract on air-pollution induced oxidative damage in traffic police officers.  Nat.Prod.Res 2008, 22, 1544 – 1551.
  43. F.Tateo, A.Ravaglioli, C.Andreoli, F.Bonina, V.Coiro, S.Degetto, A.Giaretta, A.Menconi Orsini, C.Puglia, V.Summa. The in vitro percutaneous migration of chemical elements from a thermal mud for healing use. Appl.Clay Sci. 2009, 44, 83-94.
  44. C.Puglia, F. Bonina, F.Castelli, D.Micieli, M.G. Sarpietro. Evaluation of percutaneous absorption of the repellent DEET and the sunscreen octyl methoxy cinnamate (OMC) loaded solid lipid nanoparticles: an in vitro study. J. Pharm. Pharmacol. 2009, 61, 1013-1019.
  45. C. Puglia, L. Rizza, M. Drechsler and F. Bonina. Nanoemulsions as vehicle for topical administration of glycyrrhetic acid: characterization and in vitro and in vivo evaluation. Drug Del. 2010, 17(3):123-129.
  46. C. Puglia, F. Bonina, L. Rizza, R. Cortesi, E. Merlotti, M. Drechsler, P. Mariani, C. Contado, L. Ravani, and E. Esposito. Evaluation of percutaneous absorption of naproxen from different liposomal formulations. J.Pharm.Sci. 2010, 99(6):2819-2829.
  47. L. Rizza, A. D’Agostino, A. Girlando, C. Puglia. Evaluation of the effect of topical agents on radiation induced skin disease by reflectance spectrophotometry. J. Pharm. Pharmacol. 2010, 62(6): 779-785.
  48. L. Rizza, G. Frasca, C. Bonina and C. Puglia. Comparative in vivo study of efficacy and tolerance of exfoliating agents using reflectance spectrophotometric methods. J.Cosm.Sci. 2010, 61(3):247-258.
  49. C. Puglia, M. G. Sarpietro, F.Bonina, F.Castelli, M. Zammataro, S. Chiechio. Development, characterization and in vitro and in vivo evaluation of benzocaine and lidocaine loaded nanostructured lipid carriers (NLC). J.Pharm.Sci. 2011, 100(5):1892-1899.
  50. P. Blasi, S. Giovagnoli, A. Schoubben, C. Puglia, F. Bonina, C. Rossi, M. Ricci. Lipid nanoparticles for brain targeting I. Formulation optimization. Int.J.Pharm. 2011, 419, 287– 295.
  51. C. Puglia, F. Bonina, L. Rizza, P. Blasi, A. Schoubben, R. Perrotta, M. S. Tarico, E. Damiani. Lipid nanoparticles as carrier for octyl-methoxycinnamate (OMC): in vitro percutaneous absorption and photo-stability studies. J.Pharm.Sci. 2012, 101(1): 301-311.
  52.  L. Rizza, G. Frasca, M. Nicholls, C. Puglia, V. Cardile. Caco-2 cell line as a model to evaluate mucoprotective proprieties. Int. J. Pharm. 2012, 422(1-2): 318-322.
  53. A. Crovara Pescia, P. Astolfi, C. Puglia, F. Bonina, R. Perrotta, B. Herzog, E. Damiani.  On the assessment of photostability of sunscreens exposed to UVA irradiation: from glass plates to pig/human skin, which is best? Int. J. Pharm. 2012, 427 (2): 217–223.
  54.  C. Puglia and F.Bonina. Lipid nanoparticles as novel delivery systems for cosmetics and dermal pharmaceuticals. Expert Opin. Drug Del.  2012, 9(4): 429-441.
  55.  L. Rizza, C. Bonina, G. Frasca, C. Puglia. Skin-whitening effects of Mediterranean herbal extracts by in vitro and in vivo models J. Cosm. Sci. 2012, 63(5): 311-320.
  56.  C. Puglia, G. Frasca, T. Musumeci, L. Rizza, G. Puglisi, F. Bonina, S. Chiechio. Curcumin loaded NLC induces histone hypoacetilation in the CNS after intraperitoneal administration in mice. Eur. J. Pharm. Biopharm. 2012, 81: 288-293.
  57.  G. Frasca, V. Cardile, C. Puglia, C. Bonina, F. Bonina. Gelatin tannate reduces the proinflammatory effects of lipopolysaccharide in human intestinal epithelial cells. Clin. Exp. Gastroenterol. 2012, 5: 61-67.
  58.  C. Puglia, G.G. Tirendi, F. Bonina. Emerging Role of Colloidal Drug Delivery Systems (CDDS) in NSAIDs Topical Administration. Curr.Med.Chem. 2013, 20 (14): 1847-1857.
  59. C. Puglia, V. Cardile, A.M. Panico, L. Crascì, A. Offerta, S. Caggia, M. Drechsler, P. Mariani, R. Cortesi and E. Esposito. Evaluation of monooleine aqueous dispersions as tools for topical administration of curcumin: characterization, in vitro and ex-vivo studies. J.Pharm.Sci. 2013, 102(7): 2349-2361.
  60. F. Brugè, E. Damiani, C. Puglia, A. Offerta, T. Armeni, G.Littarru, L. Tiano. Nanostructured lipid carriers loaded with CoQ10: effect on human dermal fibroblasts under normal and UVA-mediated oxidative conditions. Int. J. Pharm. 2013, 455(1-2): 348-356.
  61. C. Puglia, A. Offerta, L. Rizza, G. Zingale, F. Bonina, S. Ronsisvalle. Optimization of curcumin loaded lipid nanoparticles formulated using high shear homogenization (HSH) and ultrasonication (US) methods. J. Nanosci. Nanotechnol. 2013, 13(10): 6888-6893.
  62. E. Esposito, L. Ravani, P. Mariani, C. Contado, M. Drechsler, C. Puglia, R. Cortesi. Curcumin containing monoolein aqueous dispersions: A preformulative study. Mat. Sci. Eng. C-Mater 2013, 33: 4923-4934.
  63. C. Puglia, L. Rizza, A. Offerta, F. Gasparri, V. Giannini, F. Bonina. Formulations strategies to modulate the topical delivery of anti-inflammatory compounds. J. Cosm. Sci. 2013, 64(5): 341-353.
  64. C. Puglia, E. Damiani, A. Offerta, L. Rizza, G. G. Tirendi, M.S. Tarico, S. Curreri, F. Bonina, and R.E. Perrotta. Evaluation of nanostructured lipid carriers (NLC) and nanoemulsions as carriers for UV-filters: characterization, in vitro penetration and photostability studies. Eur. J. Pharm. Sci. 2014, 51C: 211-217.
  65. E. Esposito, L. Ravani, P. Mariani, N. Huang, P. Boldrini, S. Mosbah, M. Drechsler, G.pe Valacchi, R.Cortesi and C. Puglia. Effect of nanostructured lipid vehicles on percutaneous absorption of curcumin. Eur. J. Pharm. Biopharm. 2014, 86: 121-132.
  66. C. Puglia, A. Offerta, A. Saija, D. Trombetta, V. Cardile. Protective effect of red orange extract supplementation against UV-induced skin damages: photo-aging and age lentigines. J. Cosmet. Dermatol. 2014, 13: 151-157.
  67. C. Puglia, A. Offerta, C. Carbone, F. Bonina, R. Pignatello and G. Puglisi. Lipid Nanocarriers (LNC) and their Applications in Ocular Drug Delivery. Curr.Med.Chem. 2015, 22 (13): 1589-1602.
  68. F. Brugè, E. Damiani, F. Marcheggiani, A. Offerta, C. Puglia, L. Tiano. A comparative study on the possible cytotoxic effects of different nanostructured lipid carrier (NLC) compositions in human dermal fibroblasts. . Int. J. Pharm. 2015, 495 (2): 879–885.
  69. R. Pignatello, C. Carbone, C. Puglia, A. Offerta, F.P. Bonina, G. Puglisi. Ophthalmic applications of lipid-based drug nanocarriers: an update of research and patenting activity. Ther.Del. 2015, 6(11): 1297-1318. doi: 10.4155/tde.15.73.
  70. E. Esposito, L. Ravani, P. Mariani, C. Puglia, S. Mazzitelli, N. Huang, R. Cortesi, C. Nastruzzi. Gelified reverse micellar dispersions as percutaneous formulations. J. Drug Deliv. Sci. Technol. 2016, 32: 270-282.
  71. A. Offerta, F. Bonina, F. Gasparri, A. Zanardi, L. Micicchè, C. Puglia. In vitro percutaneous absorption of niacinamide and phytosterols and in vivo evaluation of their effect on skin barrier recovery. Curr. Drug. Deliv. 2016, 13: 111-120.
  72. C.Puglia, A.Offerta, G.G.Tirendi, M.S.Tarico, S.Curreri, F.Bonina, and R.E. Perrotta. Design of solid lipid nanoparticles for caffeine topical administration. Drug Deliv. 2016, 23(1): 36-40. doi: 10.3109/10717544.2014.903011.
  73. D. Tronino, A. Offerta, C. Ostacolo, R. Russo, C. De Caro, A. Calignano, C. Puglia, P. Blasi. Nanoparticles prolong N-palmitoylethanolamide anti-inflammatory and analgesic effects in vivo. Colloids and Surfaces B: Biointerfaces. 2016, 141: 311–317.
  74. Esposito E, Drechsler M, Huang N, Pavoni G, Cortesi R, Santonocito D, Puglia C. Ethosomes and organogels for cutaneous administration of crocin. Biomed Microdevices. 2016, 18(6):108.
  75. Esposito E, Drechsler M, Mariani P, Panico AM, Cardile V, Crascì L, Carducci F, Graziano AC, Cortesi R, Puglia C. Nanostructured lipid dispersions for topical administration of crocin, a potent antioxidant from saffron (Crocus sativus L.). Mater Sci Eng C Mater Biol Appl. 2017 ;71:669-677.
  76. C. Puglia, M.R. Lauro, G.G. Tirendi, G.E. Fassari, C. Carbone, F. Bonina, G. Puglisi. Modern drug delivery strategies applied to natural active compounds. Expert Opin Drug Deliv. 2017; 14(6):755-768. doi: 10.1080/17425247.2017.1234452.
  77. C. Puglia, M.R. Lauro, A. Offerta, L. Crascì, L. Micicchè, A.M. Panico, F. Bonina and G. Puglisi. Nanostructured Lipid Carriers (NLC) as Vehicles for Topical Administration of Sesamol: in Vitro Percutaneous Absorption Study and Evaluation of Antioxidant Activity. Planta Med.2017; 83(5):398-404. doi: 10.1055/s-0042-105293.
  78. Crascì L, Basile L, Panico A, Puglia C, Bonina FP, Basile PM, Rizza L, Guccione S. Correlating in Vitro Target-Oriented Screening and Docking: Inhibition of Matrix Metalloproteinases Activities by Flavonoids. Planta Med. 2017, 83(11):901-911

 - Caratterizzazione di sistemi di rilascio di farmaci

- Formulazione di sistemi nanoparticellari a matrice lipidica (SLN e NLC)

- Formulazione di nanocarriers per la veicolazione di molecole attive

- Valutazione dell'assorbimento percutaneo di farmaci e di ingredienti attivi cosmetici

- Valutazione della stabilità di sistemi nanoparticellari e vescicolari

- Formulazione di micro e nanoemulsioni per l'applicazione topica di attivi di interesse farmaceutico e cosmetico