SYSTEMATIC TOXICOLOGY

To provide relevant information to the knowledge of the toxic effects of substances of considerable environmental importance and their impact on organs and systems

Traditional lecture

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1° module: Risk assessment and toxicity

Biomonitoring of populations exposed to environmental xenobiotics. Bioindicators and biomarkers as sensors of biological response. Biotic indices.
Mechanisms of toxicity: genotoxicity, embryotoxicity, carcinogenesis, cell death and apoptosis.

2° module: Food toxicology

The food chain and its key role in the transfer of xenobiotics from the environment to living organisms.

• Bacterial toxins
• Animal and vegetable toxins; mycotoxins

• Nitrosamines and nitrous compounds
• Food additives
• Toxicity from veterinary dugs residues

3° module: Toxic substances of considerable environmental relevance

• Organochlorine, organophosphates and pyrethroids insecticides. Herbicides. Fungicides and rodenticides. Exposure, mechanism, toxic effects.
• Solvents: benzene, chlorinated aliphatic hydrocarbons, ethanol, methanol, glycols. Exposure, mechanism and toxic effects, general and specific
• Structure and toxicity of solid materials and biomaterials. Pathogenicity of fibers and particles: silica, asbestos
• Metals: arsenic, cadmium, chromium, lead, mercury, nickel, iron, manganese. Exposure, mechanism, toxic effects.
• Substances inducing hemoglobin alteration: carbon monoxide, cyanide, xenobiotics in general. Exposure, mechanism, toxic effects.
• Toxicity of household substances
• Antidotes

1) Galli, Corsini, Marinovich, Tossicologia – Piccin

2) Hodgson, Tossicologia- Edises

3) Casarett & Doull's: Tossicologia EMSI

Texts for insights

4) Paoletti, Nicosia, Clementi, Fumagalli: Ecotossicologia UTET

5) Paoletti, Nicosia, Clementi, Fumagalli: Tossicologia molecolare e cellulare UTET

6) Paoletti, Nicosia, Clementi, Fumagalli: Tossicologia degli alimenti UTET