TOXICOLOGY

To provide the basis for a correct evaluation of drug side effects. To provide the notions for understanding how to use chemotherapeutic drugs and biological drugs. Understanding of the mechanisms underlying addiction and abuse.

Classroom lessons

Principles of toxicology – Therapeutic index and margin of safety; unwanted side effects; acute, subacute and chronic toxicities, toxicological aspects of drug absorption, distribution and excretion.

Cellular and molecular toxicology – Mechanisms of cell death; molecular basis of programmed cell death; pharmacological regulation of cellular toxicity; molecular mechanisms of cancerogenesis and teratogenesis; drug metabolism-induced toxicity; genetic polymorphism and drug interactions; molecular mechanisms of immunotoxicity; molecular mechanisms of neurotoxicity.

Drugs with selective toxicity: 1) a detailed compendium of all antibacterial, antiviral, antimycotic, and anti-malaric drugs; 2) antineoplastic drugs; 3) immunosupressants and biological modifiers.

Drug abuse - The neurobiology of drug abuse; effects of psycostimulants, allucinogens, cannabis derivatives, opioids, anabolic steroids, ethanol, nicotine.

Goodman & Gilman's - The Pharmacological Basis of Therapeutics.

Casarett and Doulls Toxicology - The Basic Science of Poisons.