CHIMICA FARMACEUTICA E TOSSICOLOGICA II

The education goal of the course is to provide students with the tools to study the fundamental concepts that characterize Medicinal and Toxicological Chemistry. Selected classes of drugs that interact with neurotransmitter receptors, with intracellular receptors, with enzymes and with ionic channels will be examined, investigating their mechanisms of action and chemical-pharmaceutical properties.

The intended training objective is to provide the student with the skills necessary to understand the problems related to the design, the mechanism of action at the molecular level, the drug-receptor interactions, the toxicity, and the structure-activity relationships of the classes of drugs taken in exam

The course will be carried out mainly by means of frontal lessons. During class lectures, all the subjects are presented in details. Students are asked to actively discuss about them and about a number of case studies.

Should teaching be carried out in mixed mode or remotely, it may be necessary to introduce changes with respect to previous statements, in line with the programme planned and outlined in the syllabus.

Learning assessment may also be carried out on line, should the conditions require it.

Drugs acting on the cholinergic system

Drugs acting on the adrenergic system

Drugs acting on histaminergic receptors. Antiallergic and antigastrolesive drugs

Non-steroidal anti-inflammatory drugs (NSAID)

Drugs for Parkinson's therapy

Anxiolytic drugs

Antipsychotic drugs

Antidepressant drugs

Opioid analgesics

Antihypertensive drugs

Other

1. G.L. PATRICK, Chimica Farmaceutica, III Edizione italiana, EdiSES, Napoli, 2015

2. T.L. LEMKE et al., Foye's L'essenziale, Principi di Chimica Farmaceutica, I Edizione italiana, Piccin, Padova, 2017.

3. A. GASCO, F. GUALTIERI, C. MELCHIORRE, Chimica Farmaceutica, CEA, Milano, 2015

4. D.A. WILLIAMS, T.L. LEMKE, Foye's Principi di Chimica Farmaceutica, VI Edizione italiana, Piccin, Padova, 2014.

5. Slides presented during classes