PHARMACEUTICAL CHEMISTRY and TOXICOLOGY II

Academic Year 2022/2023 - Teacher: Loredana SALERNO

Expected Learning Outcomes

The education goal of the course is to provide students with the tools to study the fundamental concepts that characterize Medicinal and Toxicological Chemistry. Selected classes of drugs that interact with neurotransmitter receptors, with intracellular receptors, with enzymes and with ionic channels will be examined, investigating their mechanisms of action and chemical-pharmaceutical properties.

The intended training objective is to provide the student with the skills necessary to understand the problems related to the design, the mechanism of action at the molecular level, the drug-receptor interactions, the toxicity, and the structure-activity relationships of the classes of drugs taken in exam

Course Structure

The course will be carried out mainly by means of frontal lessons. During class lectures, all the subjects are presented in details. Students are asked to actively discuss about them and about a number of case studies.

Should teaching be carried out in mixed mode or remotely, it may be necessary to introduce changes with respect to previous statements, in line with the programme planned and outlined in the syllabus.

Learning assessment may also be carried out on line, should the conditions require it.

Detailed Course Content

Drugs acting on the cholinergic system

Drugs acting on the adrenergic system

Drugs acting on histaminergic receptors. Antiallergic and antigastrolesive drugs

Non-steroidal anti-inflammatory drugs (NSAID)

Drugs for Parkinson's therapy

Anxiolytic drugs

Antipsychotic drugs

Antidepressant drugs

Opioid analgesics

Antihypertensive drugs

Other

Textbook Information

1. G.L. PATRICK, Chimica Farmaceutica, III Edizione italiana, EdiSES, Napoli, 2015

2. T.L. LEMKE et al., Foye's L'essenziale, Principi di Chimica Farmaceutica, I Edizione italiana, Piccin, Padova, 2017.

3. A. GASCO, F. GUALTIERI, C. MELCHIORRE, Chimica Farmaceutica, CEA, Milano, 2015

4. D.A. WILLIAMS, T.L. LEMKE, Foye's Principi di Chimica Farmaceutica, VI Edizione italiana, Piccin, Padova, 2014.

5. Slides presented during classes

Course Planning

 SubjectsText References
1Agenti attivi sul sistema colinergico1,2,3
2Agenti attivi sul sistema adrenergico1,2,3
3Agenti attivi sui recettori istaminergici. Farmaci antiallergici e antigastrolesivi1,2,3
4Farmaci antinfiammatori non steroidei1 e 2
5Farmaci per la terapia del Parkinson1 e 2
6Farmaci ansiolitici1 e 2
7Farmaci antipsicotici1 e 2
8Farmaci antidepressivi1 e 2
9Analgesici oppioidi1 e 2
10Farmaci antipertensivi1,2,3