Toxicology
Academic Year 2022/2023 - Teacher: Agata Graziella COPANIExpected Learning Outcomes
Course Structure
Required Prerequisites
Attendance of Lessons
Detailed Course Content
Principles of toxicology – Therapeutic index and margin of safety; unwanted side effects; acute, subacute and chronic toxicities, toxicological aspects of drug absorption, distribution and excretion;drug metabolism-induced toxicity; genetic polymorphism and drug interactions.
Cellular and molecular toxicology – Mechanisms of cell death; molecular basis of programmed cell death; pharmacological regulation of cellular toxicity; molecular mechanisms of cancerogenesis and teratogenesis.
Drugs with selective toxicity: 1) a detailed compendium of all antibacterial, antiviral, antimycotic, and anti-malaric drugs; 2) antineoplastic drugs; 3) immunosupressants and biological modifiers.
Drug abuse - The neurobiology of drug abuse; effects of psycostimulants, allucinogens, cannabis derivatives, opioids, anabolic steroids, ethanol, GHB, nicotine.
Textbook Information
Course Planning
| Subjects | Text References | |
|---|---|---|
| 1 | Principles of toxicology – Therapeutic index and margin of safety; unwanted side effects; acute, subacute and chronic toxicities, toxicological aspects of drug absorption, distribution and excretion; drug metabolism-induced toxicity; genetic polymorphism and drug interactions | 5 |
| 2 | Cellular and molecular toxicology – Mechanisms of cell death; molecular basis of programmed cell death; pharmacological regulation of cellular toxicity; molecular mechanisms of cancerogenesis and teratogenesis | 5 |
| 3 | Antibacterial chemotherapeutic agents: bacterial resistance and selection criteria | 5 |
| 4 | Drugs with selective toxicity: a detailed compendium of antibacterial drugs | 5 |
| 5 | Drugs with selective toxicity: a detailed compendium of antimycotic drugs | 5 |
| 6 | Drugs with selective toxicity: a detailed compendium of anti-malaric drugs | 5 |
| 7 | Drugs with selective toxicity: a detailed compendium of antiviral drugs | 5 |
| 8 | Drugs with selective toxicity: a detailed compendium of antineoplastic drugs | 5 |
| 9 | Drugs with selective toxicity: a detailed compendium of immunosupressants and biological modifiers. | 5 |
| 10 | Drug abuse - The neurobiology of drug abuse; effects of psycostimulants, allucinogens, cannabis derivatives, opioids, anabolic steroids, ethanol, GHB, nicotine. | 5 |