| Anno | Titolo | Tipo MIUR |
|---|
| 2025 | Design and Synthesis of Tetrahydropyrrolo[3,4‐c]Pyrazole Sigma‐1 Receptor Ligands
(CHEMMEDCHEM) | Articolo in rivista |
| 2025 | Enhancing HDAC Inhibitor Screening: Addressing Zinc Parameterization and Ligand Protonation in Docking Studies
(INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES) | Articolo in rivista |
| 2025 | HDAC/σ1R Dual-Ligand as a Targeted Melanoma Therapeutic
(PHARMACEUTICALS) | Articolo in rivista |
| 2025 | Novel sigma 1-antagonists with cis-(+)-normetazocine scaffold: synthesis, molecular modeling, and antinociceptive effect
(RSC MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2025 | Targeting histone deacetylase 1: Inhibition and activation as promising therapeutic strategies for diverse disorders
(EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2024 | Analgesici oppioidi | Contributo in volume (Capitolo o Saggio) |
| 2024 | Design, Synthesis, and Cytotoxic Assessment of New Haloperidol Analogues as Potential Anticancer Compounds Targeting Sigma Receptors
(MOLECULES) | Articolo in rivista |
| 2024 | Design, Synthesis, and Evaluation of Novel (−)‐cis‐N‐Normetazocine Derivatives: In Vitro and Molecular Modeling Insights
(CHEMICAL BIOLOGY & DRUG DESIGN) | Articolo in rivista |
| 2024 | Exploring Structural Requirements for Sigma-1 Receptor Linear Ligands: Experimental and Computational Approaches
(JOURNAL OF CHEMICAL INFORMATION AND MODELING) | Articolo in rivista |
| 2024 | In vitro and in vivo studies of ocular topically administered NLC for the treatment of uveal melanoma
(INTERNATIONAL JOURNAL OF PHARMACEUTICS) | Articolo in rivista |
| 2024 | Investigation of Tau-Dependent Epigenetic Reprogramming in Alzheimer’s Disease | Abstract in Atti di convegno |
| 2024 | Mechanisms of the Antineoplastic Effects of New Fluoroquinolones in 2D and 3D Human Breast and Bladder Cancer Cell Lines
(CANCERS) | Articolo in rivista |
| 2024 | Sigma-1 receptor targeting inhibits connexin 43 based intercellular communication in chronic neuropathic pain
(INFLAMMATION RESEARCH) | Articolo in rivista |
| 2024 | Synthesis and biological evaluation of novel σ1R ligands | Contributo in Atti di convegno |
| 2024 | W/O/W Microemulsions for Nasal Delivery of Hydrophilic Compounds: A Preliminary Study
(JOURNAL OF PHARMACEUTICAL SCIENCES) | Articolo in rivista |
| 2023 | Cytotoxicity Profiles and Neuroprotective Properties of the Novel Ifenprodil Analogues as Sigma Ligands
(MOLECULES) | Articolo in rivista |
| 2023 | Design of Small Molecules for Oncological and Neurodegenerative Diseases | Poster |
| 2023 | Design, synthesis, in vitro evaluation, and molecular modeling studies of N-substituted benzomorphans, analogs of LP2, as novel MOR ligands
(CHEMICAL BIOLOGY & DRUG DESIGN) | Articolo in rivista |
| 2023 | DESIGN, SYNTHESIS, MOLECULAR MODELING AND PHARMACOLOGICAL EVALUATION OF NOVEL DIAZABICYCLO[4.3.0]NONANE AND 2,7-DIAZASPIRO[3.5]NONANE AS SIGMA RECEPTORS LIGANDS | Poster |
| 2023 | Designing drugs optimized for both blood-brain barrier permeation and intra-cerebral partition
(EXPERT OPINION ON DRUG DISCOVERY) | Articolo in rivista |
| 2023 | Discovery and computational studies of piperidine/piperazine-based compounds endowed with sigma receptor affinity
(RSC MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2023 | Discovery of AD258 as a Sigma Receptor Ligand with Potent Antiallodynic Activity
(JOURNAL OF MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2023 | Discovery of first novel sigma/HDACi dual-ligands with a potent in vitro antiproliferative activity
(BIOORGANIC CHEMISTRY) | Articolo in rivista |
| 2023 | Discovery of SI 1/20 and SI 1/22 as Mutual Prodrugs of 5-Fluorouracil and Imidazole-Based Heme Oxygenase 1 Inhibitor with Improved Cytotoxicity in DU145 Prostate Cancer Cells
(CHEMMEDCHEM) | Articolo in rivista |
| 2023 | Dual Piperidine-Based Histamine H3 and Sigma-1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain
(JOURNAL OF MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2023 | Nanostructured lipid carrier for the ophthalmic delivery of haloperidol metabolite II valproate ester (±)-MRJF22: A potential strategy in the treatment of uveal melanoma
(JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY) | Articolo in rivista |
| 2023 | New Insights into the Opioid Analgesic Profile of cis-(-)-N-Normetazocine-derived Ligands
(MOLECULES) | Articolo in rivista |
| 2023 | Novel N-normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics for Pain Treatment | Contributo in Atti di convegno |
| 2023 | NOVEL N-NORMETAZOCINE DERIVATIVES WITH SIGMA-1 RECEPTOR ANTAGONIST PROFILE AS POTENTIAL ANALGESICS FOR INFLAMMATORY PAIN MANAGEMENT | Poster |
| 2023 | Potential treatment of uveal melanoma with (S)-(–)-MRJF22 loaded-nanostructured lipid carriers: preliminary in vitro and in vivo studies | Contributo in Atti di convegno |
| 2023 | Preliminary in vitro and in vivo studies of (S)-(–)-MRJF22 loaded-NLC for potential treatment of uveal melanoma | Abstract in Atti di convegno |
| 2023 | SYNTHESIS, COMPUTATIONAL INSIGHTS, AND EVALUATION OF NOVEL SIGMA RECEPTORS LIGANDS | Contributo in Atti di convegno |
| 2023 | Synthesis, Computational Insights, and Evaluation of Novel Sigma Receptors Ligands
(ACS CHEMICAL NEUROSCIENCE) | Articolo in rivista |
| 2022 | A new Sigma-1 Receptor antagonist in Chronic Pain Treatment: (+)-2R/S-LP2 effects in inflammatory and neuropathic pain | Contributo in Atti di convegno |
| 2022 | Correction to Nitric Oxide Photo-Donor Hybrids of Ciprofloxacin and Norfloxacin: A Shift in Activity from Antimicrobial to Anticancer Agents
(JOURNAL OF MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2022 | Design, synthesis, and biological evaluation of new hybrid MOR agonist/HDACi compounds: an innovative approach for persistent pain management | Contributo in Atti di convegno |
| 2022 | Design, synthesis and biological evaluation of novel aminopropylcarboxamide derivatives as sigma ligands
(BIOORGANIC & MEDICINAL CHEMISTRY LETTERS) | Articolo in rivista |
| 2022 | Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation
(EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2022 | Haloperidol metabolite II Valproate ester-loaded NLC as promising strategy for the treatment of Uveal Melanoma | Contributo in Atti di convegno |
| 2022 | Hybrid MOR agonist/HDACi molecules as potential antinociceptive multi-target drugs: design, synthesis, and biological evaluation | Abstract in Atti di convegno |
| 2022 | MOR/DOR Dual-Target Approach:
2S-LP2 Effects in Inflammatory and Neuropathic Pain | Contributo in Atti di convegno |
| 2022 | Mu and Delta Opioid Receptor Targeting Reduces Connexin 43-Based Heterocellular Coupling during Neuropathic Pain
(INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES) | Articolo in rivista |
| 2022 | NLC as promising platform to deliver new prodrugs in the treatment of ophthalmic cancer | Abstract in Atti di convegno |
| 2022 | NLC for the delivery of new prodrugs in the treatment of uveal melanoma | Abstract in Atti di convegno |
| 2022 | Novel N-normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics in Inflammatory Pain
(MOLECULES) | Articolo in rivista |
| 2022 | Novel Tyrosine Kinase Inhibitors to Target Chronic Myeloid Leukemia
(MOLECULES) | Articolo in rivista |
| 2022 | Structural and Molecular Insight into Piperazine and Piperidine Derivatives as Histamine H3 and Sigma-1 Receptor Antagonists with Promising Antinociceptive Properties
(ACS CHEMICAL NEUROSCIENCE) | Articolo in rivista |
| 2022 | Structure-activity relationships of mixed σ1R/σ2R ligands with antiproliferative and anticancer effects
(BIOORGANIC & MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2022 | W/O/W nanoemulsions as a potential platform for nasal delivery of hydrophilic compounds: a preliminary study | Abstract in Atti di convegno |
| 2021 | Design, Synthesis and biological evaluation of hybrid MOR agonist/ HDACi molecules as potential therapeutic agents for chronic pain treatment | Poster |
| 2021 | Design, synthesis and biological evaluation of MOR agonist/HDACi hybrid compounds: a new potential therapeutic strategy for persistent pain management | Abstract in Atti di convegno |
| 2021 | Haloperidol Metabolite II Valproate Ester (S)-(-)-MRJF22: Preliminary Studies as a Potential Multifunctional Agent Against Uveal Melanoma
(JOURNAL OF MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2021 | Hybrid MOR agonist/HDACi molecules as potential new drugs for persistant pain management: design, synthesis and biological evaluation | Poster |
| 2021 | Interaction of new sigma ligands with biomembrane models evaluated by differential scanning calorimetry and Langmuir-Blodgett studies
(COLLOIDS AND SURFACES. B, BIOINTERFACES) | Articolo in rivista |
| 2021 | Nanostructured lipid carriers for the potential intranasal administration of essential oils | Abstract in Atti di convegno |
| 2021 | Nitric Oxide Photo-Donor Hybrids of Ciprofloxacin and Norfloxacin: A Shift in Activity from Antimicrobial to Anticancer Agents
(JOURNAL OF MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2021 | Recent Advances in the Development of Sigma Receptor Ligands as Cytotoxic Agents: A Medicinal Chemistry Perspective
(JOURNAL OF MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2021 | Solid lipid nanoparticles for sorafenib ophthalmic delivery | Abstract in Atti di convegno |
| 2021 | The Multimodal MOPr/DOPr Agonist LP2 Reduces Allodynia in Chronic Constriction Injured Rats by Rescue of TGF-β1 Signalling
(FRONTIERS IN PHARMACOLOGY) | Articolo in rivista |
| 2020 | Exploiting the Power of Stereochemistry in Drug Action: 3-[(2S,6S,11S)-8-Hydroxy-6,11-dimethyl-1,4,5,6-tetrahydro-2,6-methano-3-benzazocin-3(2H)-yl]-N-phenylpropanamide as Potent Sigma-1 Receptor Antagonist
(ACS CHEMICAL NEUROSCIENCE) | Articolo in rivista |
| 2020 | New arylethanolimidazole derivatives as HO-1 inhibitors with cytotoxicity against MCF-7 breast cancer cells
(INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES) | Articolo in rivista |
| 2020 | Novel N-Substituted Benzomorphan-Based Compounds: From MOR-Agonist/DOR-Antagonist to Biased/Unbiased MOR Agonists
(ACS MEDICINAL CHEMISTRY LETTERS) | Articolo in rivista |
| 2020 | Sigma Receptor Ligands Carrying a Nitric Oxide Donor Nitrate Moiety: Synthesis, In Silico, and Biological Evaluation
(ACS MEDICINAL CHEMISTRY LETTERS) | Articolo in rivista |
| 2020 | Synthesis and Molecular Modelling Studies of New 1,3-Diaryl-5-Oxo-Proline Derivatives as Endothelin Receptor Ligands
(MOLECULES) | Articolo in rivista |
| 2020 | Tuning Properties for Blood-Brain Barrier Permeation: A Statistics-Based Analysis
(ACS CHEMICAL NEUROSCIENCE) | Articolo in rivista |
| 2019 | CNS permeability parameters determination through a statistical analysis driven approach | Abstract in Atti di convegno |
| 2019 | Development of NO-releasing sigma receptor hybrids as anticancer agents | Abstract in Atti di convegno |
| 2019 | Development of novel H2S-donor sigma receptor hybrids for the management of pain. | Abstract in Atti di convegno |
| 2019 | Fourfold filtered statistical/computational approach for the identification of imidazole compounds as HO-1 inhibitors from natural products
(MARINE DRUGS) | Articolo in rivista |
| 2019 | From Haloperidol to new selective sigma receptor ligands | Contributo in Atti di convegno |
| 2019 | Heme Oxygenase-2 (HO-2) as a therapeutic target: Activators and inhibitors
(EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2019 | Influenza del N-sostituente della (–)-cis-N-Normetazocina nella modulazione del profilo funzionale al MOR, DOR e KOR: da agonista ad antagonista attraverso ligandi misti agonisti/antagonisti | Abstract in Atti di convegno |
| 2019 | La modellistica molecolare applicata ai recettori Sigma-1 e Sigma-2: un excursus | Abstract in Atti di convegno |
| 2019 | Morphing of ibogaine: A successful attempt into the search for sigma-2 receptor ligands
(INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES) | Articolo in rivista |
| 2019 | Synthesis, in vitro and in silico studies of HO-1 inducers and lung antifibrotic agents
(FUTURE MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2019 | Synthesis, in vitro and in vivo characterization of new benzoxazole and benzothiazole-based sigma receptor ligands
(EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2019 | Synthesis of “no-light activated” Ciprofloxacin and Norfloxacin derivatives as potential biofilm dispersant agents | Abstract in Atti di convegno |
| 2018 | A pseudouridine isoxazolidinyl nucleoside analogue structural analysis: A morphological approach
(MOLECULES) | Articolo in rivista |
| 2018 | A structure-and ligand-based virtual screening of a database of “small” marine natural products for the identification of “blue” sigma-2 receptor ligands
(MARINE DRUGS) | Articolo in rivista |
| 2018 | Benzomorphan scaffold for opioid analgesics and pharmacological tools development: A comprehensive review
(EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2018 | Benzomorphan skeleton, a versatile scaffold for different targets: A comprehensive review
(EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2018 | Design, synthesis, and pharmacological evaluation of NO donor-sigma receptors hybrids for the treatment of cancer | Abstract in Atti di convegno |
| 2018 | Effect of sigma ligands, (+)-MR200 and (−)-MRV3, on DMPC biomembrane model: DSC study | Abstract in Atti di convegno |
| 2018 | Effect of sigma ligands, (+)-MR200 anf (-)-MRV3, on DMPC biomembrane model: DSC study | Poster |
| 2018 | Effects of Polyphenolic Derivatives on Heme Oxygenase-System in Metabolic Dysfunctions
(CURRENT MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2018 | Identification of Potentially Potent Heme Oxygenase 1 Inhibitors through 3D-QSAR Coupled to Scaffold-Hopping Analysis
(CHEMMEDCHEM) | Articolo in rivista |
| 2018 | (+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties
(JOURNAL OF MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2018 | Molecular modeling studies of pseudouridine isoxazolidinyl nucleoside analogues as potential inhibitors of the pseudouridine 5'-monophosphate glycosidase
(CHEMICAL BIOLOGY & DRUG DESIGN) | Articolo in rivista |
| 2018 | New homo and hetero bis-arylpiperazine and bis-benzylpiperazine derivatives as 5-HT7R selective ligands: design and synthesis | Abstract in Atti di convegno |
| 2018 | New selective Sigma-1/HDACi prodrugs for neurodegenerative disorders | Abstract in Atti di convegno |
| 2018 | Novel Sigma-1 receptor antagonists: From opioids to small molecules: What is new?
(FUTURE MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2018 | Novel structural insight into inhibitors of heme oxygenase-1 (ho-1) by new imidazole-based compounds: Biochemical and in vitro anticancer activity evaluation
(MOLECULES) | Articolo in rivista |
| 2018 | Potholing of the hydrophobic heme oxygenase-1 western region for the search of potent and selective imidazole-based inhibitors | Abstract in Atti di convegno |
| 2018 | Potholing of the hydrophobic heme oxygenase-1 western region for the search of potent and selective imidazole-based inhibitors
(EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2018 | Synthesis and Structure-Activity Relationships of LP1 Derivatives: N-Methyl-N-phenylethylamino Analogues as Novel MOR Agonists
(MOLECULES) | Articolo in rivista |
| 2018 | Targeting heme Oxygenase-1 with hybrid compounds to overcome Imatinib resistance in chronic myeloid leukemia cell lines
(EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2017 | Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review
(EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2017 | (+)-and (−)-Phenazocine enantiomers: evaluation of their dual opioid agonist/σ1 antagonist properties and antinociceptive effects
(EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2017 | Comprehensive data on a 2D-QSAR model for Heme Oxygenase isoform 1 inhibitors
(DATA IN BRIEF) | Articolo in rivista |
| 2017 | Development of a Sigma-2 Receptor affinity filter through a Monte Carlo based QSAR analysis
(EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES) | Articolo in rivista |
| 2017 | Development of Sigma Receptors Nitric Oxide Photodonor Ligands with Antiproliferative Activity | Abstract in Atti di convegno |
| 2017 | Effect of MRJF4 on C6 Glioma Cells Proliferation and Migration
(CENTRAL NERVOUS SYSTEM AGENTS IN MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2017 | Heme Oxygenase Database (HemeOxDB) and QSAR Analysis of Isoform 1 Inhibitors
(CHEMMEDCHEM) | Articolo in rivista |
| 2017 | Hyphenated 3D-QSAR statistical model-scaffold hopping analysis for the identification of potentially potent and selective sigma-2 receptor ligands
(EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2017 | Nanoencapsulation strategies for the delivery of novel bifunctional antioxidant/σ1 selective ligands.
(COLLOIDS AND SURFACES. B, BIOINTERFACES) | Articolo in rivista |
| 2017 | Novel Sigma Receptors Ligands-Nitric Oxide Photodonor: Molecular Hybrids for Double-Targeted Antiproliferative Effect
(JOURNAL OF MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2017 | (+)-Pentazocine attenuates SH-SY5Y cell death, oxidative stress and microglial migration induced by conditioned medium from activated microglia
(NEUROSCIENCE LETTERS) | Articolo in rivista |
| 2017 | Recent advances in drug discovery of phototherapeutic non-porphyrinic anticancer agents
(EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2017 | Repurposing of human kinase inhibitors in neglected protozoan diseases
(CHEMMEDCHEM) | Articolo in rivista |
| 2017 | Role of the Nrf2/HO-1 axis in bronchopulmonary dysplasia and hyperoxic lung injuries
(CLINICAL SCIENCE) | Articolo in rivista |
| 2017 | Sigma-1 and Sigma-2 receptor ligands induce apoptosis and autophagy but have opposite effect on cell proliferation in uveal melanoma
(ONCOTARGET) | Articolo in rivista |
| 2017 | Sigma-2 receptor ligands QSAR model dataset
(DATA IN BRIEF) | Articolo in rivista |
| 2017 | Synthesis and evaluation of haloperidol metabolite II prodrugs as anticancer agents
(FUTURE MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2017 | Synthesis of Novel Benzylpiperazine Derivatives as Ligands for the σ1 Receptor | Abstract in Atti di convegno |
| 2017 | S2RSLDB: A comprehensive manually curated, internet-accessible database of the sigma-2 receptor selective ligands
(JOURNAL OF CHEMINFORMATICS) | Articolo in rivista |
| 2017 | Targeting Heme Oxygenase-1 to Overcome Imatinib Resistance in Chronic Myeloid Leukemia | Abstract in Atti di convegno |
| 2017 | Tumor Targeting Sigma Receptor Ligands: Development of New Molecular Hybrids as Anticancer Therapeutics | Abstract in Atti di convegno |
| 2016 | Antiangiogenic Effect of (±)-Haloperidol Metabolite II Valproate Ester [(±)-MRJF22] in Human Microvascular Retinal Endothelial Cells
(JOURNAL OF MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2016 | Haloperidol Metabolite II Valproate Ester: Antiangiogenic Activity in Human Microvascular Retinal Endothelial Cells | Abstract in Atti di convegno |
| 2016 | HALOPERIDOL METABOLITE II VALPROATE ESTER: ANTIANGIOGENIC ACTIVITY IN HUMAN
MICROVASCULAR RETINAL ENDOTHELIAL CELLS | Poster |
| 2016 | Heme Oxygenase-1 Inhibition: A Novel Strategy for the Design of Azole-Based Antitumour Agents | Abstract in Atti di convegno |
| 2016 | New bifunctional antioxidant/σ1 agonist ligands: preliminary chemico-physical and biological evaluation
(BIOORGANIC & MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2016 | Novel selective ligands for the serotonergic 5-HT7 receptor: tricyclic derivatives Bearing the pyrimido-4(3H)-one ring | Abstract in Atti di convegno |
| 2016 | (+)-Pentazocine reduces oxidative stress and apoptosis in microglia following
hypoxia/reoxygenation injury
(NEUROSCIENCE LETTERS) | Articolo in rivista |
| 2016 | Preparation and characterization of polymeric micelles loaded with a potential anticancer prodrug
(JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY) | Articolo in rivista |
| 2016 | Rescuing Abandoned Molecules as Nav1.7 and
PCSK9 Inhibitors
(JOURNAL OF ADVANCES IN MEDICAL AND PHARMACEUTICAL SCIENCES) | Articolo in rivista |
| 2015 | Antioxidant activity of (+)-Pentazocine on activated microglia | Abstract in Atti di convegno |
| 2015 | Antioxidant properties and pharmacokinetic studies of new selective σ1 bifunctional ligands | Abstract in Atti di convegno |
| 2015 | Chemistry and Biology of Salinomycin and Its Analogues
(TARGETS IN HETEROCYCLIC SYSTEMS: CHEMISTRY AND PROPERTIES) | Articolo in rivista |
| 2015 | Haloperidol metabolite II prodrug: Asymmetric synthesis and biological evaluation on rat C6 glioma cells
(EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2015 | MRJF4, a novel histone deacetylase inhibitor, induces p21 mediated autophagy in PC3 prostate cancer cells
(CELLULAR AND MOLECULAR BIOLOGY) | Articolo in rivista |
| 2015 | New 5-Ht7 Receptor Ligands As Potential Antidepressant Agents. | Poster |
| 2015 | Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines
(EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2015 | Role of new bifunctional sigma-1 selective ligands with antioxidant activity on activated microglia. | Poster |
| 2015 | 4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes
(RSC ADVANCES) | Articolo in rivista |
| 2014 | Effects of a Selective Sigma 1 Antagonist Compound on Inflammatory Pain
(INFLAMMATION) | Articolo in rivista |
| 2014 | Structure-activity relationships and molecular modelling of new 5-arylidene-4-thiazolidinone derivatives as aldose reductase inhibitors and potential anti-inflammatory agents
(EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2014 | The antagonistic effect of the sigma 1 receptor ligand (+)-MR200 on persistent pain induced by inflammation.
(INFLAMMATION RESEARCH) | Articolo in rivista |
| 2013 | Crystal morphologies and polymorphs in tolbutamide microcrystalline powder
(JOURNAL OF PHARMACEUTICAL SCIENCES) | Articolo in rivista |
| 2013 | Re-valuation of the Inverse Docking technique to compute drugs in multi-target studies | Poster |
| 2013 | Synthesis and biological evaluation of new benzo-thieno[3,2-d]pyrimidin-4-one sulphonamide thio-derivatives as potential selective cyclooxygenase-2 inhibitors
(MOLECULAR DIVERSITY) | Articolo in rivista |
| 2013 | The multitarget opioid ligand LP1's effects in persistent pain and in primary cell neuronal cultures
(NEUROPHARMACOLOGY) | Articolo in rivista |
| 2012 | Antinociceptive profile of LP1, a non-peptide multitarget opioid ligand.
(LIFE SCIENCES) | Articolo in rivista |
| 2012 | THE BENZOMORPHAN-BASED LP1 IS A CENTRAL-ACTING MULTITARGET OPIOID LIGAND FOR CHRONIC PAIN TREATMENT | Poster |
| 2012 | The benzomorphan-based LP1 ligand is a suitable MOR/DOR agonist for chronic pain
treatment
(LIFE SCIENCES) | Articolo in rivista |
| 2011 | Anti-amnesic and neuroprotective actions of the sigma-1 receptor agonist (-)-MR22 in rats with selective cholinergic lesion and amyloid infusion
(JOURNAL OF ALZHEIMER'S DISEASE) | Articolo in rivista |
| 2011 | Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells
(EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2011 | Apoptotic effects of (±) MRJF4 in prostate cancer cells | Poster |
| 2011 | How molecular interactions affect crystal morphology: the case of haloperidol
(JOURNAL OF PHARMACEUTICAL SCIENCES) | Articolo in rivista |
| 2011 | Novel potent and selective σ ligands: evaluation of their agonist and antagonist properties
(JOURNAL OF MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2010 | Evaluation of N-substitution in 6,7-benzomorphan compounds
(BIOORGANIC & MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2010 | Opiate Receptors and Antagonists: From Bench to Clinic. Edited by R. Dean, E. J. Bilsky, and S. S. Negus
(CHEMMEDCHEM) | Articolo in rivista |
| 2009 | Anti-amnesic properties of (+/-)-PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats
(JOURNAL OF NEUROCHEMISTRY) | Articolo in rivista |
| 2009 | Neuroprotective effect of the new sigma receptor ligands cis-(+) and cis-(–)-PPCC | Contributo in Atti di convegno |
| 2009 | Novel compounds as promising anti-proliferative agents in cancer cell lines | Contributo in Atti di convegno |
| 2009 | Synthesis and pharmacological evaluation of novel series of (+)-MR-200 derivatives | Contributo in Atti di convegno |
| 2009 | Synthesis of MRJF4 enentiomers and evaluation of proapoptotic and cytotoxic effects in cancer cell lines | Contributo in Atti di convegno |
| 2008 | A new sigma ligand, (+/-)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect
(LIFE SCIENCES) | Articolo in rivista |
| 2008 | Copper-Catalyzed Coupling Reaction of 2-Thioxo-4-quinazolinone and Thieno[3,2-d]pyrimidin-4-one Methane Sulphonamide with Aryl Iodide : Preparation of Potential COX-2 Selective Inhibitors
(SYNTHETIC COMMUNICATIONS) | Articolo in rivista |
| 2008 | (+)-Mr200 derivatives: modifications on the amino moiety. In vitro and in vivo pharmacological evaluation | Contributo in Atti di convegno |
| 2008 | New selective sigma receptor ligands cis-(+) and cis-(−) PPCC: in vitro and in vivo studies | Poster |
| 2008 | Phenytoin differentially modulates the affinity of sigma1 receptor ligands: studies with newly synthesized sigma1 compounds
(METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY) | Articolo in rivista |
| 2008 | Proapoptotic and cytotoxic effects of MRJF4 on human prostate cancer | Contributo in Atti di convegno |
| 2008 | Proapototic and cytotoxic effects of MRJF4 in prostate cancer cell lines | Contributo in Atti di convegno |
| 2008 | Synthesis and pharmacological evaluation of MRJF4 as new potential anticancer tool
(DRUGS OF THE FUTURE) | Poster |
| 2007 | Benzomorphan-based opioid ligands with mixed m agonist/d antagonist activity | Contributo in Atti di convegno |
| 2007 | Effect of a new sigma ligand, (±)PPCC, on KOP receptor mediated analgesia | Contributo in Atti di convegno |
| 2007 | (+)-MR200 derivatives as potential new selective sigma ligands | Contributo in Atti di convegno |
| 2007 | (+)-MR200 derivatives as potenzial new selective ligands | Contributo in Atti di convegno |
| 2007 | MR22, a novel sigma-1 receptor agonist: Effects on lesioned-induced memory dysfunction and amyloid deposition in rats | Contributo in Atti di convegno |
| 2007 | New (+)- and (–)-1-phenyl-3-azabicyclo[3.1.0]hexanes as probes for sigma receptors | Contributo in Atti di convegno |
| 2007 | New benzomorphan derivatives of MPCB as MOP and KOP receptor ligands
(PHARMAZIE) | Articolo in rivista |
| 2007 | Novel Sigma Receptor Ligands: Synthesis and Biological Profile
(JOURNAL OF MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2007 | Restorative effects of sigma1 receptor ligands in a rat model of cholinergic loss, amyloid deposition and cognitive dysfunction | Contributo in Atti di convegno |
| 2006 | A novel adamantane derivative attenuates retinal ischemia-reperfusion damage in the rat retina through sigma1 receptors
(EUROPEAN JOURNAL OF PHARMACOLOGY) | Articolo in rivista |
| 2006 | Evaluation of (–)-MR22 a novel sigma-1 receptor ligand on lesion-induced memory dysfunctions in the rat
(DRUGS OF THE FUTURE) | Articolo in rivista |
| 2006 | In vivo evaluation of (+)-MR200 as a new selective sigma ligand modulating MOP, DOP and KOP supraspinal analgesia
(LIFE SCIENCES) | Articolo in rivista |
| 2006 | Methyl 2-[(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)methyl]-1-phenylcyclopropane-carboxylate enantiomers. Design, synthesis and pharmacological evaluation of opioid receptor affinities | Contributo in Atti di convegno |
| 2006 | Synthetic Approaches to Bridgehead Nitrogen Methanesulfonamide Derivatives of 3-Amino-2-thioxo-2,3-dihydrothieno[2,3-d]pyrimidin-4(1H)-ones, Potential COX-2 Selective Inhibitors
(JOURNAL OF HETEROCYCLIC CHEMISTRY) | Articolo in rivista |
| 2005 | Methanesulphonamide of 3,5-dihydro-4H-pyrimido[5,4-b]indol4-one and [1]Benzothieno[3,2-d]pirimidin-4(3H)-one derivatives as potential COX-2 inhibitors | Contributo in Atti di convegno |
| 2005 | Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity
(NEUROREPORT) | Articolo in rivista |
| 2005 | Synthesis and pharmacological evaluation of new 1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one derivatives as new potential selective NOP ligands
(SCIENTIA PHARMACEUTICA) | Articolo in rivista |
| 2004 | VALUTAZIONE FARMACOLOGICA DEL LIGANDO SIGMA (+)-MR200 E DEGLI ALTRI ENANTIOMERI NELLA MODULAZIONE DELL’ANALGESIA INDOTTA DALLE DIVERSE SOTTOPOPOLAZIONI RECETTORIALI OPPIOIDI | Poster |
| 2004 | Valutazione farmacologica del ligando sigma (+)-MR200 e degli altri enantiomeri nell’analgesia indotta dalle diverse sottopopolazioni recettoriali oppioidi | Contributo in Atti di convegno |
| 2004 | 1-Phenyl-3azabicyclo[3.1.0]hexane derivatives as new ligands for sigma receptors
(ARKIVOC) | Articolo in rivista |
| 2003 | Intrastriatal administration of sigma ligands inhibits basal dopamine release in vivo
(NEUROPHARMACOLOGY) | Articolo in rivista |
| 2003 | Synthesis and effects on the COX-1 and COX-2 activity in Human Whole Blood ex vivo of derivatives containing the [1]benzothienol[3,2-d]pyrimidin-4-one heterocyclic system
(ARCHIV DER PHARMAZIE) | Articolo in rivista |
| 2003 | Synthesis of potential selective COX-2 enzyme inhibitors derived from ethyl ester of 2-isothiocyanato-5-phenyl-3-thiophenecarboxylic acid
(JOURNAL OF HETEROCYCLIC CHEMISTRY) | Articolo in rivista |
| 2002 | Effect of (-)-MR22, a Novel Sigma-1 Receptor Ligand, Against Ischemia/Reperfusion Damage in Rat Retina | Contributo in Atti di convegno |
| 2002 | Effetti neuroprotettivi dell’ (-)-MR22, un nuovo sigma-1 agonista selettivo, sul danno ischemico retinico | Contributo in Atti di convegno |
| 2002 | Neuroprotective effect of (-)-MR22, a novel sigma-1 receptor ligand, on ischemic injury in the rat retina | Contributo in Atti di convegno |
| 2002 | Sigma receptor binding profile of a series of analgesic tropane derivatives
(ARCHIV DER PHARMAZIE) | Articolo in rivista |
| 2002 | SIMULTANEOUS DETERMINATION OF AMPHETAMINE AND ONE OF ITS METABOLITES BY HPLC WITH ELECTROCHEMICAL DETECTION
(JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS) | Articolo in rivista |
| 2002 | Synthesis of (+)- and (-)-cis-2-[(1-adamantylamino)-methyl]-1-phenylcyclopropane derivatives as high affinity probes for sigma1 and sigma2 binding sites
(IL FARMACO) | Articolo in rivista |
| 2002 | Synthesis of (+)-cis-N-(4-isothiocyanatobenzyl)-N-normetazocine, an isothiocyanate derivative of N-benzylnormetazocine as acylant agent for the sigma(1) receptor
(JOURNAL OF MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2001 | Methyl 1-phenyl-2-{[(2,6,6-trimethylbicyclo[3.1.1]hept-3-yl)amino]methyl}cyclopropane-carboxylate diastereoisomers as potent and enantioselective sigma-1 and sigma-2 ligands | Contributo in Atti di convegno |
| 2001 | Novel methyl-2-[4-[(4-hydroxy-4-phenylpiperidin-1-yl)methyl]-1-phenylcyclopropane-carboxylate derivatives as sigma-1 and sigma-2 receptor ligands | Abstract in Atti di convegno |
| 2001 | NOVEL 1-PHENYL-2-{[(2,6,6-TRIMETHYLBICYCLO[3.1.1]HEPT-3-YL)AMINO]METHYL}CYCLOPROPANECARBOXYLATE DIASTEREOISOMERS AS POTENT AND ENANTIOSELECTIVE SIGMA-1 AND SIGMA-2 LIGANDS | Contributo in Atti di convegno |
| 2001 | Opioid and sigma receptor studies. New developments in the design of selective sigma ligands
(PURE AND APPLIED CHEMISTRY) | Articolo in rivista |
| 2001 | PHARMACOLOGICAL EVALUATION OF POTENT SIGMA LIGANDS IN β-AMYLOID INDUCED NEURODEGENERATION | Abstract in Atti di convegno |
| 2001 | PHARMACOLOGICAL EVALUATION OF POTENT SIGMA LIGANDS IN β-AMYLOID INDUCED NEURODEGENERATION | Contributo in Atti di convegno |
| 2001 | Specific kappa opioid receptor agonists
(IL FARMACO) | Articolo in rivista |
| 2001 | Synthesis and binding affinity of cis-(–)- and cis-(+)-N-ethyleneamino-N-nordeoxymetazocine and cis-(–)-N-normetazocine analogues at σ1, σ2 and κ opioid receptors
(EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES) | Articolo in rivista |
| 2001 | Synthesis and pharmacological evaluation of potent and enantioselective sigma-1 and sigma-2 ligands
(IL FARMACO) | Articolo in rivista |
| 2001 | SYNTHESIS OF BNIT AN ISOTHIOCYANATE DERIVATIVE OF N-BENZYL-NORMETAZOCINE AS ACYLANT AGENT FOR σ1 RECEPTOR | Contributo in Atti di convegno |
| 2000 | Nonpeptide Analogues of Dynorphin A(1-8): Design, Synthesis, and Pharmacological Evaluation of k-Selective Agonists
(JOURNAL OF MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2000 | Specific kappa opioid receptor agonists
(IL FARMACO) | Articolo in rivista |
| 2000 | Substituted 1-phenyl-2-cyclopropylmethylamines with high affinity and selectivity for sigma sites
(BIOORGANIC & MEDICINAL CHEMISTRY) | Articolo in rivista |
| 2000 | Synthesis and pharmacological evaluation of potent and enantioselective sigma-1 and sigma-2 ligands | Contributo in Atti di convegno |
| 2000 | Synthesis of (+) and (−)-cis-2-[(1-adamantylamino)-methyl]-1-phenylcyclopropane derivatives as probe for sigma-1 and sigma-2 binding sites | Contributo in Atti di convegno |
| 1998 | (+)-cis-N-ethyleneamino-N-normetazocine derivatives. Novel and selective sigma
ligands with antagonist properties
(JOURNAL OF MEDICINAL CHEMISTRY) | Articolo in rivista |
| 1997 | SYNTHESIS OF (+)-(1'R,2'S) AND (1'S,2'R)-6,11-DIMETHYL-1,2,3,4,5,6-HEXAHYDRO-3-[[2'-(ALKOXYCARBONYL)-2'-PHENYLCYCLOPROPYL]METHYL]-2,6-METHANO-3-BENZAZOCIN-8-OL. COMPARISON OF THE AFFINITIES FOR SIGMA 1 AND OPIOID RECEPTORS WITHIN THE DIASTEREOISOMERIC MPCB AND CCB
(IL FARMACO) | Articolo in rivista |
| 1996 | PEPTIDOMIMETICS OF THE KAPPA-OPIOID RECEPTOR. A HYBRID MPCB /PEPTIDE LIGAND (MPCB-RRI) BINDS KAPPA CLONED RECEPTOR WITH NANOMOLAR AFFINITY
(ANALGESIA) | Articolo in rivista |
| 1996 | Progettazione, Sintesi e Profilo Farmacologico di Ligandi Sigma-Selettivi | Contributo in Atti di convegno |
| 1996 | Synthesis, physical properties, toxicological studies and bioavailability of L-pyroglutamic and L-glutamic acid esters of paracetamol as potentially useful prodrugs
(JOURNAL OF PHARMACY AND PHARMACOLOGY) | Articolo in rivista |
| 1995 | CCB, a novel specific kappa opioid agonist, which discriminates between opioid
and sigma 1 recognition sites
(LIFE SCIENCES) | Articolo in rivista |
| 1995 | New developments in opioid receptors ligands
(ARS PHARMACEUTICA) | Articolo in rivista |
| 1995 | Selective Ligands for Sigma1 Receptors with Agonist or Antagonist Properties | Contributo in Atti di convegno |
| 1995 | Synthesis and antimicrobial evaluation of 4-phenyl-3-isoquinolinoyl-hydrazones
(IL FARMACO) | Articolo in rivista |
| 1995 | Synthesis, physical properties ans toxicological studies of L-pyroglutamic and L-glutamic acid esters of acetamininophen as potentially useful prodrugs | Contributo in Atti di convegno |
| 1991 | Methoctramine-related polymethylene tetraamines. 4(1)-chirality effect on M2 muscarinic receptor blocking activity
(IL FARMACO) | Articolo in rivista |