Academic Year 2018/2019 - 2° Year - Curriculum Scienze Erboristiche e dei Prodotti Nutraceutici
Teaching Staff: Maria Assunta Rossella CHIACCHIO
Credit Value: 6
Scientific field: CHIM/06 - Organic chemistry
Taught classes: 42 hours
Term / Semester:

Learning Objectives

The course aims to provide students with the basis for understanding Organic Chemistry, its applicative aspects and its connections with the field of herbal and nutraceuticals sciences through the study of the most important organic compounds.

Course Structure

The course takes place trough frontal lessons

Detailed Course Content

INTRODUCTION TO ORGANIC CHEMISTRY. Atomic structure. The chemical bond. Isomerism. Acids and bases.
ALKANES. Nomenclature. Structure. sp3 hybridization. σ- bond. Conformations. Chemical and physical properties. Reactions.
CYCLOALKANES. Nomenclature. Geometric isomerism. Conformations.
ALKENES. Nomenclature. sp2 Hybridization. Structure. π-bond. Configurational isomerism. Physical and chemical properties. Electropilic additions: Markovnikov rule, carbocation stabilization.
DIENES. Nomenclature. Conjugated dienes. Resonance. Addition 1,2 and 1,4.
ALKYNE. Nomenclature. sp hybridization. Chemical and physical properties. Acidity. Electrophilic additions.
AROMATIC HYDROCARBONS. Benzene. Structure, resonance energy, aromaticity. Nomenclature of derivatives. Aromatic electrophilic substitutions: mechanism and effect of substituents on reactivity and orientation. Polycyclic aromatic hydrocarbons.
STEREOCHEMISTRY. Enantiomers and chirality. Diastereoisomers. Resolution of a raceme. Molecular models.
HALID. Nomenclature. Chemical and physical properties. Nucleophilic substitution: stereochemistry. Elimination reaction. Elimination versus substitutions. Aryl halides.
ALCOHOLS. Nomenclature. Structure. Hydrogen bond. Preparations. Acidity, oxidation and dehydration. Glycols.
PHENOL. Nomenclature. Structure. Acidity.
ETHERS. Nomenclature. Structure. Chemical properties. Cyclic ethers. Epoxides.
ALDEIDS AND CHETONS. Nomenclature. Carbonyl group structure. Preparations. Nucleophilic addition, mechanism. Oxidation. Reduction. Reaction of enolate ions. α-halogenation. α,β-Unsaturated aldehydes and ketones
CARBOSSILIC ACIDS AND THEIR DERIVATIVES. Nomenclature. Acidity. Unsaturated acids. Preparations. Esterification. Saponification. Acylic nucleophilic substitution. Acyl halides. Anhydrides. Amides.
DIFUNCTION ACIDS. Bicarboxylic acids. Hydroxy Acids. Lactoni and lactids. Keto acids. Claisen condensation.
AMINES. Nomenclature. Structure and chemical and physical properties. Basicity. Reactions of amines as nucleophiles Diazonium salts.
HETEROCYLIC COMPOUNDS. Pyrrole, furan, thiophene, imidazole. Pyridine, pyrimidine, indole (outline).
CARBOHYDRATES. Nomenclature. Stereoisomery. Acyclic and cyclic structures of monosaccharides. Disaccharides and polysaccharides.
AMINOACIDS AND PROTEINS. Structure and dipolar ions. Acidity and basicity. Isoelectric point. Geometry of the peptide bond. Levels of protein structure.

Textbook Information

1) H. Hart C. M. Hadad, L. E. Craine, D. J. Hart- Chimica Organica VII edizione- Zanichelli editore S. p. A. – Via Irnerio 34- 40126 Bologna.

2) W. H. BROWN, T. POON – Introduzione alla Chimica Organica IV edizione – EdiSES S.r.l. - Via nuova S. Rocco, 62/A – Soleado – Napoli.

3) B. BOTTA – Chimica Organica Essenziale – Edi. Ermes s.r.l. Viale E. Forlanini, 65 – 20134 Milano