Systematic toxicology
Academic Year 2023/2024 - Teacher: VINCENZO MICALEExpected Learning Outcomes
To provide relevant information to the knowledge of the toxic effects of substances of considerable environmental importance and their impact on organs and systems
Course Structure
Traditional lecture. Should teaching be carried out in mixed mode or remotely, it may be necessary to introduce changes with respect to previous statements, in line with the programme planned and outlined in the syllabus.
Information for students with disabilities and / or SLD:
To guarantee equal opportunities and in compliance with the laws in force, interested students can ask for a personal interview in order to plan any compensatory and / or dispensatory measures, based on the didactic objectives and specific needs.
It is also possible to contact the referent teacher CInAP (Center for Active and Participated Integration - Services for Disabilities and / or SLD) of our Department, Prof. Teresa Musumeci
Required Prerequisites
Attendance of Lessons
Detailed Course Content
1° module: Risk assessment and toxicity
Biomonitoring of populations exposed to environmental xenobiotics. Bioindicators and biomarkers as sensors of biological response. Biotic indices.
Mechanisms of toxicity: genotoxicity, embryotoxicity, carcinogenesis, cell death and apoptosis.
2° module: Food toxicology
The food chain and its key role in the transfer of xenobiotics from the environment to living organisms.
- Bacterial toxins
- Animal and vegetable toxins; mycotoxins
- Nitrosamines and nitrous compounds
- Food additives
- Toxicity from veterinary dugs residues
3° module: Toxic substances of considerable environmental relevance
- Organochlorine, organophosphates and pyrethroids insecticides. Herbicides. Fungicides and rodenticides. Exposure, mechanism, toxic effects.
- Solvents: benzene, chlorinated aliphatic hydrocarbons, ethanol, methanol, glycols. Exposure, mechanism and toxic effects, general and specific
- Structure and toxicity of solid materials and biomaterials. Pathogenicity of fibers and particles: silica, asbestos
- Metals: arsenic, cadmium, chromium, lead, mercury, nickel, iron, manganese. Exposure, mechanism, toxic effects.
- Substances inducing hemoglobin alteration: carbon monoxide, cyanide, xenobiotics in general. Exposure, mechanism, toxic effects.
- Toxicity of household substances
- Antidotes
Textbook Information
1) Galli, Corsini, Marinovich, Tossicologia – Piccin
2) Hodgson, Tossicologia- Edises
3) Casarett & Doull's: Tossicologia EMSI
Texts for insights
4) Paoletti, Nicosia, Clementi, Fumagalli: Ecotossicologia UTET
5) Paoletti, Nicosia, Clementi, Fumagalli: Tossicologia molecolare e cellulare UTET
6) Paoletti, Nicosia, Clementi, Fumagalli: Tossicologia degli alimenti UTET
Course Planning
Subjects | Text References | |
---|---|---|
1 | Biomonitoraggio della popolazione esposta a xenobiotici ambientali | 1, 2, 3, 4 |
2 | Indici biotici | 4 |
3 | Meccanismi di tossicità: genotossicità, tossicità embrionale, cancerogenesi, morte cellulare ed apoptosi. Tossicità d'organo | 1, 2, 3, 5 |
4 | Tossine batteriche | 1, 3 |
5 | Tossine di origine animale e vegetale | 1, 3, 5 |
6 | Micotossine | 1, 3, 6 |
7 | Nitrosoammine e nitrosocomposti | 1, 3, 6 |
8 | Additivi alimentari | 1, 3, 6 |
9 | Tossicità derivante da presenza di farmaci ad uso veterinario | 6 |
10 | Insetticidi organoclorurati, organofosforici e piretroidi. Erbicidi. Fungicidi e rodenticidi. Esposizione, meccanismo, effetti tossici | 1, 2, 3 |
11 | Solventi e vapori: benzene, idrocarburi alifatici clorurati, etanolo, metanolo, glicoli. Esposizione, meccanismo ed effetti tossici, generali e specifici | 1, 3 |
12 | Struttura e tossicità dei materiali solidi e dei biomateriali. Patogenicità di fibre e particolato: silice, amianto | 1, 3, 5 |
13 | I metalli: arsenico, cadmio, cromo, piombo, mercurio, nichel, ferro, manganese. Esposizione, meccanismo, effetti tossici | 1, 2, 3 |
14 | Sostanze inducenti alterazione dell'emoglobina: monossido di carbonio, cianuro, xenobiotici in genere. Esposizione, meccanismo, effetti tossici | 1, 3, 5 |
15 | Antidoti | 3 |
16 | Tossicità di sostanze ad uso domestico | 5 |
17 | Biomateriali | 5 |