Pharmaceutical Chemistry - CHEMICAL-TOXICOLOGICAL ANALYSIS OF OFFICINAL PLANTS AND NUTRACEUTICAL PRODUCTS

Module CHEMICAL-TOXICOLOGICAL ANALYSIS OF OFFICINAL PLANTS AND NUTRACEUTICAL PRODUCTS

This course introduces the principles of analytical chemistry and provides how these principles are applied in the analysis of plants active principles and nutraceuticals.

The aim of this course is to provide students with a broad understanding of the principles and applications of analytical chemistry. Students are first provided with an introduction into sample collection and preparation, analytical measurements and statistical treatment of data that can be obtained from a variety of analytical methods compehensive of the basic instrumental methods of chemical analysis. This course will cover important titrimetric methods: acid-base, complexometric and redox titrations, as titrimetric techniques still play an important role in the modern analytical laboratory, to a large extent because many titrations can be fully automated.The students will also be introduced to basic separation techniques, e.g. solvent extraction and ion-exchange including chromatography. The teaching offers the basic knowledge for the assessment of some analytical methods suitable for the analysis of the active principles present in medicinal plants,  phytoderivatives and nutraceuticals  and to carry out the quality control of the herbal products, according to the certification standards of the quality systems.

On successful completion of the course students will be able to:

1. Describe and compare a range of analytical chemistry methods and explain the underlying theoretical principles.

2. Employ a variety of analytical and instrumental methods to prepare, separate and quantify active principles and neutraceticals.

3. Apply the scientific process, including statistical treatment of data, in the conduct and reporting of chemical analysis.

4. Work safely and competently in an analytical laboratory setting.

Frontal Lessons.

Theory is brought to practice in the laboratory if possible or through videos.

According to  "Regolamento Didattico di Ateneo (R.D.A.) i.e. University Didactic Regulations attendance of both lessons and laboratory training  is mandatory.

Should teaching be carried out in mixed mode or remotely, it may be necessary to introduce changes with respect to previous statements, in line with the programme planned and outlined in the syllabus.

Information for students with disabilities and / or SLD: To guarantee equal opportunities and in compliance with the laws in force, interested students can ask for a personal interview in order to plan any compensatory and / or dispensatory measures, based on the teaching objectives and specifications needs. It is also possible to contact the CInAP contact person (Center for Active and Participatory Integration - Services for Disabilities and / or SLD) of the Department of Drug and Health Sciences prof. Teresa Musumeci.

Organic Chemistry.

1. Measurements, Statistics

2. Sample Preparation

3. Acid-Base Equilibria and Titrations

4. Complexation Equilibria and Titrations, EDTA titration

5. Redox Chemistry and Titrations

6. Electroanalytical Methods: electrolysis and electrodeposition coulometry, polarography

7. Spectrophotometry: fundamentals and applications, absorption and emission of radiation, spectra, Beer's law relationship between absorption and concentration, instruments for UV-visible spectrophotometry, choosing a spectrophotometric method, techniques of spectrophotometric determination 

8. Atomic Spectroscopy: atomic absorption spectroscopy, flame emission spectroscopy, plasma and electric discharge spectroscopy

9.Separation: Precipitation, Solvent extraction, Ion-exchange

10. Chromatography: principles of chromatograhy, gas chromatography, liquid chromatography

1)Daniel C Harris, FONDAMENTI DI CHIMICA ANALITICA QUANTITATIVA  2017, ZANICHELLI;
2) Renato Cozzi , Pierpaolo Protti , Tarcisio Ruaro Elementi di chimica analitica strumentale Terza edizione 2020, ZANICHELLI;

3)Luisa Mannina, Maria Daglia Alberto Ritieni, La chimica e gli alimenti nutrienti e aspetti nutraceutici, Casa Editrice Ambrosiana. Distribuzione esclusiva Zanichelli, 2019.

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Learning assessment may also be carried out on line, should the conditions require it.

Information for students with disabilities and / or SLD:

To guarantee equal opportunities and in compliance with the laws in force, interested students can ask the staff for an interview in order to plan any compensatory and / or dispensatory measures, based on educational objectives and specific needs.

It is also possible to contact the referent teacher CInAP (Center for Active and Participated Integration - Services for Disabilities and / or SLD) of the Drug and Health Sciences Department, Prof. Teresa Musumeci".