METODOLOGIE ANALITICHE PER LA DETERMINAZIONE DI PRINCIPI ATTIVI E PRODOTTI DELLA SALUTE - CHIMICA DEI NUTRACEUTICI E DEGLI ALIMENTI FUNZIONALI

Module METODOLOGIE ANALITICHE PER LA DETERMINAZIONE DI PRINCIPI ATTIVI E PRODOTTI DELLA SALUTE

At the end of the course, students will have acquired knowledge and skills concerning the main analytical approaches used for the characterization, identification, qualitative and quantitative determination of active ingredients and the analytical quality control of health products.

In particular, at the end of the course, students will be able to:

1. Knowledge and understanding

• describe the theoretical principles underlying the main analytical methodologies used for the determination of active ingredients and health products;
• understand the fundamentals of the spectroscopic, chromatographic and other analytical techniques covered in the course;
• describe the main analytical performance parameters, including accuracy, precision, selectivity, sensitivity, linearity, limit of detection and limit of quantification;
• understand the main aspects related to sample preparation, selection of the analytical technique and interpretation of analytical results.

2. Applying knowledge and understanding

• select an appropriate analytical methodology according to the nature of the analyte, the sample matrix and the analytical objective;
• apply the principles of analytical methodologies to the qualitative and quantitative determination of active ingredients and health products;
• interpret analytical data and results obtained using different analytical techniques;
• identify the main sources of error and variability and assess their impact on analytical results;
• use analytical performance parameters to assess the suitability of a method for its intended purpose.

3. Making judgements

• critically assess the suitability of an analytical procedure for a specific analytical problem;
• compare different analytical strategies considering performance, selectivity, sensitivity, robustness, time and required resources;
• critically interpret experimental results, identifying possible anomalies, interferences and sources of uncertainty;
• provide a reasoned justification for the selection of the most appropriate analytical methodology for a given analytical problem.

4. Communication skills

• clearly describe the principles and characteristics of the main analytical methodologies using appropriate scientific terminology;
• present and discuss analytical data and results orally and, where required, using audiovisual support;
• explain and justify methodological choices and respond appropriately to questions and requests for further clarification.

5. Learning skills

• integrate the knowledge acquired during the course with information obtained from scientific literature and technical/scientific documentation;
• independently acquire information concerning analytical methodologies not directly covered in the course;
• develop the ability to update knowledge in response to developments in analytical techniques and their applications in the field of health products.

Frontal Lessons.

Theory is brought to practice in the laboratory if possible or through videos.

According to  "Regolamento Didattico di Ateneo (R.D.A.) i.e. University Didactic Regulations attendance of both lessons and laboratory training  is mandatory.

Should teaching be carried out in mixed mode or remotely, it may be necessary to introduce changes with respect to previous statements, in line with the programme planned and outlined in the syllabus.

Information for students with disabilities and / or SLD: To guarantee equal opportunities and in compliance with the laws in force, interested students can ask for a personal interview in order to plan any compensatory and / or dispensatory measures, based on the teaching objectives and specifications needs. It is also possible to contact the CInAP contact person (Center for Active and Participatory Integration - Services for Disabilities and / or SLD) of the Department of Drug and Health Sciences prof. santina chiechio (santina.chiechio@unict.it).

Office hours for students: Monday at 4:30 p.m. and Friday at 9:00 a.m. Palazzo dell’Etna, Via San Nullo 5A, first floor, room 26

Exam dates: https://www.dsf.unict.it/it/corsi/l-29_sfa/calendario-esami

Organic Chemistry.

1. Measurements, Statistics

2. Sample Preparation

3. Acid-Base Equilibria and Titrations

4. Complexation Equilibria and Titrations, EDTA titration

5. Redox Chemistry and Titrations

6. Electroanalytical Methods: electrolysis and electrodeposition coulometry, polarography

7. Spectrophotometry: fundamentals and applications, absorption and emission of radiation, spectra, Beer's law relationship between absorption and concentration, instruments for UV-visible spectrophotometry, choosing a spectrophotometric method, techniques of spectrophotometric determination 

8. Atomic Spectroscopy: atomic absorption spectroscopy, flame emission spectroscopy, plasma and electric discharge spectroscopy

9.Separation: Precipitation, Solvent extraction, Ion-exchange

10. Chromatography: principles of chromatograhy, gas chromatography, liquid chromatography

1)Daniel C Harris, FONDAMENTI DI CHIMICA ANALITICA QUANTITATIVA  2017, ZANICHELLI;
2) Renato Cozzi , Pierpaolo Protti , Tarcisio Ruaro Elementi di chimica analitica strumentale Terza edizione 2020, ZANICHELLI;

3)Luisa Mannina, Maria Daglia Alberto Ritieni, La chimica e gli alimenti nutrienti e aspetti nutraceutici, Casa Editrice Ambrosiana. Distribuzione esclusiva Zanichelli, 2019.

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The final assessment consists of an oral examination, which may be supplemented by the presentation and discussion of a PowerPoint presentation lasting approximately 10–15 minutes.

The oral examination is designed to assess not only the student's knowledge of the course content, but also their ability to apply the acquired knowledge to the selection, interpretation and critical evaluation of analytical methodologies.

Where applicable, the PowerPoint presentation may focus on an analytical methodology, a specific application for the determination of active ingredients, or a case study concerning the analytical quality control of a health product.

Assessment Criteria

The assessment will consider the following criteria:

When a PowerPoint presentation is included, the assessment will also consider:

• scientific accuracy and relevance of the content;
• logical and coherent organization of the material;
• quality of data interpretation and use of appropriate sources;
• ability to justify methodological choices;
• clarity of presentation and ability to address questions;
• appropriateness and readability of the audiovisual material.

The presentation is considered an integral part of the oral examination and contributes to the overall assessment of the student's knowledge, ability to apply knowledge, independent judgement and communication skills.

Learning assessment may also be carried out on line, should the conditions require it.

Information for students with disabilities and / or SLD:

To guarantee equal opportunities and in compliance with the laws in force, interested students can ask the staff for an interview in order to plan any compensatory and / or dispensatory measures, based on educational objectives and specific needs.

It is also possible to contact the referent teacher CInAP (Center for Active and Participated Integration - Services for Disabilities and / or SLD) of the Drug and Health Sciences Department, Prof. Teresa Musumeci".