TECNOLOGIA FARMACEUTICA - LABORATORIO GALENICO - TECNOLOGIA COSMETICA CON ESERCITAZIONI M - Z

Module TECNOLOGIA FARMACEUTICA

The goal of the course is to provide the fundamental knowledge on the dosage forms, with particular emphasis on the role of the different components and quality controls on the final pharmaceutical form. The student will learn the nature and the classification of the excipients in order to understand the  their role in the different dosage forms and administration ways. At the end of the coarse the student should be able to understand and describe the various approaches for optimizing the therapeutic efficacy of an active ingredient.

EXPECTED LEARNING RESULTS

At the end of the course the student will be able to:

- Acquire knowledge on the categories and properties of the excipients and how they influence the final characteristics of a medicinal product in terms of quality. Overview of some industrial procedures for the production of pharmaceutical forms. Basic knowledge of quality control tests to be applied to the finished product.
- Understand the difference between the different pharmaceutical forms (liquid, solid, semi-solid) and their therapeutic purposes.
- Use the acquired knowledge in the phase of completion of the compulsory pre-degree professional internship.

The course is organized in frontal lessons.

MODULE 1 (5 credits)

Basic Technological Operations (1 credit)

Filtration, drying, freeze-drying, sterilization. Packaging and containers.

Conventional pharmaceutical forms (4 CFU)

Solids dosage forms: Powders and powdering: classification, technological properties, and controls; Granules: Classification, manufacturing processes, and excipients; chemical-physical requirements and controls; Tablets: Classification, excipients, manufacturing processes. Tablet coating (caking, film coating, gastrosoluble and gastro-resistant coatings); Capsules: Classification, excipients, manufacturing processes for hard and soft capsules, controls; Rectal Preparations and Vaginal Preparations: classification, excipients, manufacturing processes, and controls. 

Liquid pharmaceutical forms: Aqueous and hydroalcoholic solutions. Suspensions. Emulsions. Focus on surfactants as excipients in different pharmaceutical forms. Liquid preparations for oral use: syrups. 

Semi-solid dosage forms: Classification and excipients. Semi-solid preparations for skin application. Auricular pharmaceutical preparations.

Sterile dosage forms: Pharmaceutical forms for ophthalmic use (classification, excipients, chemical-physical and microbiological requirements); Pharmaceutical forms for parenteral use (classification, excipients, chemical-physical and microbiological requirements).

Pressurized pharmaceutical preparations: Nasal dosage forms; Pulmonary dosage forms: Classification, requirements, excipients, and devices for their administration.

MODULE 2 (4 credits)

Complementary areas of pharmaceutical interest (1 credit)

Traditional and modern phytotherapeutic and herbal preparations.Overview of the theoretical foundations and technology of homeopathic medicines.

Innovative Pharmaceutical Forms (3 credits)

Focus on Polymeric Materials and Modified-Release Drug Delivery; Modified-Release Pharmaceutical Forms in the different route of administrations. Advanced Drug Manufacturing Technologies. Microencapsulation; Molecular Inclusion Systems (Cyclodextrins); Micro- and Nanoemulsifying Systems. Nanomedicine: Historical Evolution and Classification of Nanoformulations in the Preclinical and Clinical Phases for the Delivery of Small Molecules. Types of nanoformulations: inorganic and organic nanoparticles, with particular attention to vesicular systems (liposomes, niosomes) and solid nanoparticles (polymeric, lipidic, hybrid).

RECOMMENDED TEXTS
1. P. Caliceti et al. - TECNOLOGIA FARMACEUTICA – prima edizione – Casa Editrice Ambrosiana, 2025.
2. M.E. Aulton – TECNOLOGIE FARMACEUTICHE Progettazione e allestimento dei medicinali. Edizioni EDRA, 2013.
3. Medicamenta VII Ed. (1° vol.) - Cooperativa Farmaceutica, Milano.

TEXTS TO CONSULT

1.  F.U.I. XII Ed. And related supplements and updates.
2.  European Pharmacopoeia
3.  T.A. Florence & D. Attwood - The chemical-physical bases of pharmaceutical technology - McMillan Press 2002.
4.  Martin - Physical Pharmacy - Lea & Febiger, Philadelphia, London.
5.  Remington's Pharmaceutical Sciences, 19th ed.
6.  Livingstone - Pharmaceutics. The science of dosage form design - Ed. ME Aulton.
7.  Educational material made available online by teachers.

The exam consists of a written test, which includes a preliminary section of multiple-choice questions and a section of open-ended questions.

The test must be integrated with an oral exam as suggested by the teacher and the student's discretion.  The written exam covers the theoretical topics covered in the Pharmaceutical Technology modules.

Information for students with disabilities and/or learning disabilities (LDs) To ensure equal opportunities and in compliance with applicable laws, interested students may request a personal interview to plan any compensatory and/or dispensatory measures, based on their learning objectives and specific needs. Professor Santina Chiechio, the CInAP (Center for Active and Participatory Integration - Services for Disabilities and/or Learning Disabilities) instructor at the Department of Pharmaceutical and Health Sciences, is available for consultation. ASSESSMENT CRITERIA (Will be adopted for the Integrated Course)

The final exam will be assessed based on the following indicators, weighted equally and consistently with those described in the expected learning outcomes (Dublin Descriptors):

- personal development skills and operational initiative;

- ability to consult and use bibliographical material;

- presentation skills;

- scientific understanding of the topic.