ANALISI DEI FARMACI E DEI PRODOTTI PER LA SALUTE 1 - ANALISI DEI FARMACI E DEI PRODOTTI PER LA SALUTE 2 A - L

Module ANALISI DEI FARMACI E DEI PRODOTTI PER LA SALUTE 1

The course aims to provide students with theoretical knowledge and practical skills for the qualitative determination of inorganic substances of pharmaceutical interest present in commercial products, by means of their chemical behavior and instrumental techniques.

Frontal lessons: 31 hours (4.5 ECTS)

Laboratory practice: 23 hours (1.5 ECTS)

Class attendance is mandatory. The maximum limit of absences allowed is 30% of the total hours of lessons.

Should teaching be carried out in mixed mode or remotely, it may be necessary to introduce changes with respect to previous statements, in line with the programme planned and outlined in the syllabus.

Learning assessment may also be carried out on line, should the conditions require it

The course aims to provide students with theoretical knowledge and practical skills for the qualitative determination of inorganic substances of pharmaceutical interest present in the commercial products, both by their chemical behaviour and by instrumental techniques. This knowledge will also be extended to some nutraceutical and natural substances. The course consists of lectures, laboratory exercitations, classroom exercises. The course program (total 6 CFU) is divided as follows:

MODULE 1 (2.5 ECTS): GENERAL INFORMATION ON LABORATORY OPERATIONS AND TECHNIQUES

General information on analytical methods. Classification, stages of an analysis, applications. Italian Official Pharmacopoeia Content (F.U.I).

Basic techniques and operations in semimicro analysis. Material and equipment in laboratories. Simple sample pretreatment procedures: dissolution, precipitation, filtration, centrifugation, decantation, extraction, pH measurement.

Safety and good practice in the laboratory. Safety and behaviour rules, hazard classes, symbols of harmful substances, safety data sheets, protective individual devices, waste disposal, accident prevention, first aid items.

Introduction to chromatographic methods. General information, classification, mechanisms, separation techniques and operating techniques. Application example: thin layer chromatography (TLC).

MODULE 2 (2.0 ECTS): INORGANIC SUBSTANCES OF PHARMACEUTICAL AND TOXICOLOGICAL INTEREST ENTERED IN F.U.I.

Chemical reactions. Type and classification;

Chemical-analytical and pharmaceutical properties of: 

carbonates, sulphites, acetates, borates, ammonium;

silver, aluminium, iron, calcium, magnesium, sodium, lithium, potassium;

halogens, oxalates, phosphates, sulphates, nitrates.

Identification reactions described in F.U.I. for the aforementioned ions - Limit essays

Case study / SISTEMATIC ANALYSIS

LABORATORY EXERCISES (1.5 ECTS)

Safety in the laboratory. Simple sample pretreatment procedures: dissolution, precipitation, filtration, centrifugation, extraction, pH measurement, analysis of simple mixtures by chromatographic methods: TLC.

Analysis of cationic and anionic species:

carbonates, acetates, borates, ammonium ion.

cation analysis: Ag⁺, Al⁺⁺⁺, Fe⁺⁺, Fe⁺⁺⁺, Ca⁺⁺, Mg⁺⁺

anion analysis: Cl^-, Br^-, I^-, C₂O₄^2-, PO₄^3-, SO₄^2-, NO^3-

analysis of cations and / or anions present in a mixture of pharmaceutical use.

Should teaching be carried out in mixed mode or remotely, it may be necessary to introduce changes with respect to previous statements, in line with the programme planned and outlined in the syllabus.

Learning assessment may also be carried out on line, should the conditions require it.

• Teaching material available on Studium for the current academic year
• ARANEO – Chimica Analitica Qualitativa - Casa Editrice Ambrosiana Milano
• F.U.I. XII°  and European Pharmacopoeia 10°
• “Agenti Chimici – Lavorare In Sicurezza” a cura di Associazione Ambiente e Lavoro (edizione aggiornata)
• F. Savelli, O. Bruno: Analisi Chimico farmaceutica, Piccin
• G. Caliendo: Manuale di Analisi Qualitativa, EdiSES
• Cozzi. P. Protti, T. Ruaro: Analisi chimica strumentale, volume C
• Hogness, Johnson, Armstrong: Analisi Qualitativa & Equilibrio Chimico, PICCIN
• Web-page suggested by the teacher