FARMACOLOGIA GENERALE E SPECIALE
Academic Year 2024/2025 - Teacher: Carmela PARENTIExpected Learning Outcomes
Objective of the course to provide the pharmacological basis useful for understanding the therapeutic use of single classes of drugs on the basis of their mechanism of action and the principles of pharmacokinetics
At the end of the course, to pass the exam, the student must demonstrate that he has acquired the knowledge related to:
- general pharmacokinetic concepts;
- general concepts of pharmacodynamics;
- mechanism of action, pharmacokinetic profile, therapeutic indications and side effects of the drugs indicated in the program
Course Structure
Face-to-face lectures
If the teaching is given in a mixed or remote mode, the necessary variations with respect to what was previously stated may be introduced, in order to respect the program envisaged and reported in the syllabus
Information for students with disabilities and / or SLD: To guarantee equal opportunities and in compliance with the laws in force, interested students can ask for a personal interview in order to plan any compensatory and / or dispensatory measures, based on the teaching objectives and specifications needs. It is also possible to contact the CInAP contact person (Center for Active and Participatory Integration - Services for Disabilities and / or SLD) of the DEPARTMENT OF DRUG AND HEALTH SCIENCES.
Required Prerequisites
Attendance of Lessons
Detailed Course Content
General Pharmacology
Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, Metabolism, and Elimination.
Pharmacokinetic parameters. Bioavailability, Volume of distribution, Clearance, half-life.
Pharmacodynamics: Classification of receptors and signal transduction mechanisms. Pharmacology of ion channels.
Drug-receptor interaction. Dose-response curves: Agonists, partial agonists, inverse agonists and antagonists. Potency and efficacy of drugs.
Pharmacogenetics and Pharmacogenomics. Tolerance. Side effects, idiosyncratic and allergic effects. teratogenicity
Drug Interactions
Systematic pharmacology
Catecholaminergic neurotransmission. Sympathomimetic and sympatholytic drugs
Cholinergic neurotransmission. Parasympathomimetic drugs. Parasympatholytic drugs.
Pharmacology of neuromuscular transmission
GABAergic neurotransmission. Drugs active on GABAergic transmission.
Glutamatergic neurotransmission
Pharmacology of cardiovascular function
-Pharmacotherapy of Hypertension
-Pharmacotherapy of Congestive Heart Failure
-Angina treatment drugs
-Anti-Arrhythmic Drugs
Drugs affecting renal system
-diuretics
Respiratory system drugs
- Antitussive drugs
- Bronchodilator drugs
Pharmacotherapy of Gastric Acidity, Peptic Ulcers, and Gastroesophageal Reflux Disease, Laxatives and antidiarrheal drugs
Pharmacology of inflammatory and allergic processes
-Autacoids and mediators of inflammation
- Antihistamin drugs
- Non-steroidal anti-inflammatory drugs
Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs
Endocrine Pancreas and Pharmacotherapy of Diabetes Mellitus
Drug Therapy for Hypercholesterolemia and Dyslipidemia
Drugs Therapy for bone metabolism
Endocrine system pharmacology
- Thyroid hormones and antithyroid drugs
- Estrogens, androgens, progestogens
Drugs for erectile dysfunction
Central Nervous System Pharmacology
-Drug therapy of Anxiety Disorders
-Hypnotics and Sedatives
-Pain Management
-Drug Therapy of Depression
-Pharmacotherapy of Psychosis
-Treatment of Parkinson Disease
-Pharmacotherapy of the Epilepsies
-General Anesthetics. Local Anesthetics
Textbook Information
Textbook information
F. Rossi, V. Cuomo, C. Riccardi-Farmacologia, Edizioni Minerva Medica
L.Annunziato, G. Di Rienzo-Trattato di farmacologia, Idelson-Gnocchi
Katzung BG- Farmacologia Generale e Clinica, Piccin
Testo di approfondimento:
Goodman and Gilman. Le basi farmacologiche della terapia. Ultima edizione. Zanichelli
Course Planning
| Subjects | Text References | |
|---|---|---|
| 1 | Principi generali di Farmacocinetica: vie di somministrazione, assorbimento, distribuzione, metabolismo ed escrezione dei farmaci | 2 |
| 2 | Parametri farmacocinetici. Biodisponibilità, volume di distribuzione, clearance, emivita di un farmaco | 2 |
| 3 | Principi generali di Farmacodinamica. Classificazione dei recettori e meccanismi di trasduzione del segnale. Farmacologia dei canali ionici | 1,2 |
| 4 | Interazione farmaco-recettore. Curve dose-risposta: Farmaci agonisti, agonisti parziali, agonisti inversi e antagonisti. Potenza ed efficacia dei farmaci | 1,2 |
| 5 | Variazione della risposta ai farmaci. Farmacogenetica e Farmacogenomica. Modificazioni recettoriali nella tolleranza. Effetti collaterali, da iperdosaggio, idiosincrasici, allergici. Teratogenesi | 1,2 |
| 6 | Interazioni tra farmaci di tipo farmacodinamico e farmacocinetico | 1,2 |
| 7 | • Neurotrasmissione catecolaminergica. Farmaci simpaticomimetici e simpaticolitici | 1,3 |
| 8 | Neurotrasmissione colinergica. Farmaci parasimpaticomimetici. Farmaci parasimpaticolitici | 1,3 |
| 9 | • Farmacologia della trasmissione neuromuscolare | 1,2 |
| 10 | Neurotrasmissione GABAergica. Farmaci attivi sulla trasmissione GABAergica | 1,2 |
| 11 | Neurotrasmissione glutammatergica | 1,2 |
| 12 | • Farmacologia del sistema cardiovascolare -Farmaci antianginosi. -Farmaci antiaritmici. -Farmaci antipertensivi. -Farmaci per il trattamento dell’insufficienza cardiaca | 1,3 |
| 13 | • Farmaci del sistema renale - Diuretici | 1 |
| 14 | • Farmacologia dell’apparato respiratorio - Farmaci antitussivi - Farmaci broncodilatatori | 1 |
| 15 | • Farmacologia del sistema gastroenterico - farmaci inibitori della secrezione acida, protettivi della mucosa gastrica ed antiulcera -antidiarroici lassativi e purganti | 1,3 |
| 16 | • Farmacologia dei processi infiammatori ed allergici -Autacoidi e mediatori dell’infiammazione -Farmaci antistaminici -Farmaci antinfiammatori non steroidei | 1,2,3 |
| 17 | Farmaci attivi sull’emopoiesi e sulla coagulazione | 1 |
| 18 | • Farmaci attivi sul metabolismo -Farmaci antidiabetici. -Farmaci antidislipidemici. Farmaci attivi sul metabolismo osseo | 1,2 |
| 19 | • Farmacologia del sistema endocrino - Ormoni tiroidei e farmaci antitiroidei - Estrogeni,androgeni, progestinici | 1,3 |
| 20 | Farmaci per la disfunzione erettile | 1,2,3 |
| 21 | • Farmacologia del Sistema nervoso centrale - Ansiolitici -Ipnoinducenti - Terapia del dolore - Antidepressivi - Antipsicotici - Farmaci del Parkinson - Farmaci antiepilettici -Anestetici generali. Anestetici locali | 1,2 |
Learning Assessment
Learning Assessment Procedures
Oral exam.
The assessment of learning can also be carried out online via Microsoft Teams, should conditions require it