CHIMICA FARMACEUTICA E TOSSICOLOGICA II
Academic Year 2020/2021 - 4° YearCredit Value: 10
Scientific field: CHIM/08 - Pharmaceutical chemistry
Taught classes: 70 hours
Term / Semester: One-year
Learning Objectives
The education goal of the course is to provide students with the tools to study the fundamental concepts that characterize Medicinal and Toxicological Chemistry. Selected classes of drugs that interact with neurotransmitter receptors, with intracellular receptors, with enzymes and with ionic channels will be examined, investigating their mechanisms of action and chemical-pharmaceutical properties.
The intended training objective is to provide the student with the skills necessary to understand the problems related to the design, the mechanism of action at the molecular level, the drug-receptor interactions, the toxicity, and the structure-activity relationships of the classes of drugs taken in exam
Course Structure
The course will be carried out mainly by means of frontal lessons. During class lectures, all the subjects are presented in details. Students are asked to actively discuss about them and about a number of case studies.
Should teaching be carried out in mixed mode or remotely, it may be necessary to introduce changes with respect to previous statements, in line with the programme planned and outlined in the syllabus.
Learning assessment may also be carried out on line, should the conditions require it.
Detailed Course Content
Drugs acting on the cholinergic system
Drugs acting on the adrenergic system
Drugs acting on histaminergic receptors. Antiallergic and antigastrolesive drugs
Non-steroidal anti-inflammatory drugs (NSAID)
Drugs for Parkinson's therapy
Anxiolytic drugs
Antipsychotic drugs
Antidepressant drugs
Opioid analgesics
Antihypertensive drugs
Other
Textbook Information
1. G.L. PATRICK, Chimica Farmaceutica, III Edizione italiana, EdiSES, Napoli, 2015
2. T.L. LEMKE et al., Foye's L'essenziale, Principi di Chimica Farmaceutica, I Edizione italiana, Piccin, Padova, 2017.
3. A. GASCO, F. GUALTIERI, C. MELCHIORRE, Chimica Farmaceutica, CEA, Milano, 2015
4. D.A. WILLIAMS, T.L. LEMKE, Foye's Principi di Chimica Farmaceutica, VI Edizione italiana, Piccin, Padova, 2014.
5. Slides presented during classes