PHARMACOLOGY AND PHARMACOTHERAPY

The main objective of the course in Pharmacology and Pharmacotherapy for students of the Degree Course in Pharmaceutical Chemistry and Technology is to provide the pharmacological basis of the therapy and the pharmacological profiles of the most commonly used drugs. During the discussion of each topic listed in the program, physiopathological aspects of the disease, the activity and adverse effects of the main classes of drugs will be described. At the end of the course the student must possess an adequate knowledge of the mechanisms of interaction between drugs and their molecular targets in order to understand therapeutic and side effects.

face-to-face lectures

GENERAL PHARMACOLOGY

Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, Metabolism, and Elimination

Pharmacodynamics: Molecular Mechanisms of Drug Action

NEUROTRANSMISSION. THE AUTONOMIC AND SOMATIC MOTOR NERVOUS SYSTEMS

Muscarinic Receptor Agonists and Antagonists

Anticholinesterase Agents

Agents Acting at the Neuromuscular Junction and Autonomic Ganglia

Adrenergic Agonists and Antagonists

5-Hydroxytryptamine (Serotonin) and Dopamine

NEUROTANMISSION AND THE CENTRAL NERVOUS SYSTEM

Drug Therapy of Depression and Anxiety Disorders

Pharmacotherapy of Psychosis and Mania

Hypnotics and Sedatives

Opioids, Analgesia, and Pain Management

General Anesthetics and Therapeutic Gases

Local Anesthetics

Pharmacotherapy of the Epilepsies

Treatment of Parkinson Disease

MODULATION OF CARDIOVASCULAR FUNCTION

Regulation of Renal Function and Vascular Volume

The Renin-Angiotensin System

Pharmacotherapy of Hypertension

Pharmacotherapy of Congestive Heart Failure

Anti-Arrhythmic Drugs

Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs

Drug Therapy for Hypercholesterolemia and Dyslipidemia

INFLAMMATION AND IMMUNOMODULATION

Histamine, Bradykinin, and Their Antagonists

Anti-Inflammatory, Antipyretic, and Analgesic Agents

Endocrine Pancreas and Pharmacotherapy of Diabetes Mellitus

Pharmacotherapy of Gastric Acidity, Peptic Ulcers, and Gastroesophageal Reflux Disease

GENERAL PRINCIPLES OF ANTIMICROBIAL THERAPY

GENERAL PRINCIPLES OF CANCER CHEMOTHERAPY

1- F. Clementi, G. Fumagalli. Farmacologia Generale e Molecolare. Quarta edizione. UTET

2- F. Rossi, V. Cuomo, C. Riccardi. Farmacologia. principi di base e applicazioni terapeutiche. Seconda edizione. Edizioni Minerva Medica.

3- Goodman and Gilman. The Pharmacological Basis of THERAPEUTICS