TECNOLOGIA FARMACEUTICA 2 - SISTEMI DI RILASCIO AVANZATO DEI FARMACI

Module TECNOLOGIA FARMACEUTICA 2

transfer of advanced knowledge on the design of a pharmaceutical form and on industrial methods relating to the preparation of medicines.

Frontal lectures and laboratory exercises. Should teaching be carried out in mixed mode or remotely, it may be necessary to introduce changes with respect to previous statements, in line with the programme planned and outlined in the syllabus.

Students may use AI as a tool to support their studies, in compliance with the applicable legislation, including legislation concerning copyright and the use of intellectual works, as described in section 5.1 of the guidelines (https://www.unict.it/it/ateneo/cidia-centro-l%E2%80%99informatica-la-digitalizzazione-e-l%E2%80%99intelligenza-artificiale).

Mandatory attendance in accordance with the provisions of the Teaching Regulations of the CTF Degree Programme, as indicated at the following link: http://www.dsf.unict.it/corsi/lm-13_ctf/regolamento-didattico

Information for students with disabilities and/or Specific Learning Disorders (SLD)

To ensure equal opportunities and in compliance with current legislation, students concerned may request a personal meeting in order to arrange any appropriate compensatory and/or exemption measures, based on the learning objectives and their specific needs.

Students may also contact the CInAP (Centre for Active and Participatory Integration – Disability and/or Specific Learning Disorders Services) faculty contact person for our Department, Prof. Santina Chiechio.

Chemical-physical properties of powders: General information. Density; Porosity; Adsorption phenomena. Drying techniques. Pellets: mechanism of pellet formation and growth; Pelletizing techniques and properties. Solutions and their properties: the physical basis of the dissolution process; factors affecting the solubility of solids in water; pH and isotonia; solution speed; colligative properties of solutions. Water as a solvent: preparation of deionized and distilled water. Water in the Official Pharmacopoeia. Drying of solutions and suspensions: spray drying; freeze-drying. Elements of rheology: General information; viscosity and Newtonian fluids; non-Newtonian fluids; determination of viscosity The colloidal state - Colloids. Electrical properties of interfaces; solubilization; stability of colloids; Colloidal systems of pharmaceutical interest. Suspensions. Wettability and particle coarsening; Flocculation and Deflocculation; Suspension formulation; bioavailability of drugs in suspension; suspension checks; stability. Sterilization- Various types of microorganisms; resistance characteristics. Thermal and non-thermal physical methods. Chemical methods. Parenteral preparations - Chemical, chemical-physical and biological requirements of injectable preparations. Perfusion fluids. Powders for injections. Notes on industrial production: premises, equipment. Ear preparations: notes on ear anatomy; auricular pharmaceutical forms: liquid, semi-solid and solid preparations. Nasal preparations: nasal administration of drugs; nasal aerosol; absorption of drugs through the nasal mucosa; devices for the administration of nasal preparations; Classification of nasal preparations. Inhalation preparations: notes on the anatomy of the lungs and airways; deposition of the drug in the airways; liquid nebulization preparations: nebulizers and liquid nebulization preparations; pressurized inhalation preparations: pressurized inhalers and pressurized inhalation preparations; powders for inhalation Pressurized pharmaceutical preparations: General information; the propellants and formulation; pressurized containers. Controlled release pharmaceutical forms and therapeutic systems - Drug targeting. Medicine packaging - materials and types

1. Colombo P. et al. Principi di Tecnologia Farmaceutica (seconda edizione) - Casa Editrice Ambrosiana

2. Amorosa M. Principi di Tecnica Farmaceutica (sesta edizione) - Piccin

3. Aulton M. et al. Tecnologie Farmaceutiche - Progettazione e allestimento dei medicinali - Edra

4. Caliceti P. Tecnologia Farmaceutica - Casa Editrice Ambrosiana

knowledge will be assessed through an oral interview which will cover the topics reported in the program.