Prodotti della ricerca / Research products

Di seguito vengono riportati i prodotti della ricerca dell’anno 2025, suddivisi in: A) pubblicazioni scientifiche; B) poster/comunicazioni orali a congressi nazionali/internazionali.

A. Pubblicazioni scientifiche pubblicate nell’anno 2025, riportanti il Centro NANOMED come afferenza di uno o più autori:

1. Conti F, Lazzara F, Thermos K, Zingale E, Spyridakos D, Romano G L, Martino S, Micale V, Kuchar M, Spadaro A, Pignatello R, Rossi S, D’ Amico M, Platania C M B, Drago F, Bucolo, C. Retinal pharmacodynamic and pharmacokinetic profile of cannabidiol in an in vivo model of retinal excitotoxicity. European Journal of Pharmacology, 2025, 991, 177323.
2. Zingale E, Masuzzo S, Lajunen T, Reinisalo M, Rautio J, Consoli V, D’Amico A G, Vanella L, Pignatello R. Protective Role and Enhanced Intracellular Uptake of Curcumin in Retinal Cells Using Self-Emulsifying Drug Delivery Systems (SNEDDS). Pharmaceuticals, 2025, 18(2), 265.
3. Bonaccorso A, Zingale E, Caruso G, Privitera A, Carbone C, Lo Faro M J, Caraci F, Musumeci T, Pignatello R. Design of Polycation-Functionalized Resveratrol Nanocrystals for Intranasal
   Administration. Pharmaceutics, 2025, 17(10), 1346.
4. Sarpietro, M.G.; Santonocito, D.; Greco, G.; Russo, S.; Puglia, C.; Montenegro, L. Bemotrizinol-Loaded Lipid Nanoparticles for the Development of Sunscreen Emulsions. Colloids Interfaces 2025, 9, 54. https://doi.org/10.3390/colloids9050054.
5. Hind Bouaam, Mohamed El Ouaarabi, Said Melliani, Maria Alessandra Ragusa. Existence of ground state solutions for a class of bi-non-local Kirchhoff-type problems with variable exponents. Partial Differential Equations in Applied Mathematics, 2025, 14, 101201.
6. Salamone S, Manin S, Musumeci T, Carbone C, Bonaccorso A, Rodriguez-Rodriguez R, Pignatello R. Brain targeting for the treatment of obesity: update of current knowledge and potential applications of nanomedicine and peptide conjugation. Expert Opinion on Drug Delivery. 2025, 6:1-16.
7. Bonaccorso A, Zingale E, Carbone C, Musumeci T, & Pignatello R. A current overview of polyions and polyelectrolyte complexes for pharmaceutical applications with special emphasis to brain purposes. Journal of Pharmaceutical Investigation, 2025, 1-29.
8. Battaglia L, Ini' C, Lo Bianco M, Leonardi R, Ini' E, Foti PV, Palmucci S, Fichera M, Ruggieri M, Basile A. Pilomatricomas in a patient with Rubinstein-Taybi syndrome: diagnostic and therapeutic clues. Ther Adv Rare Dis. 2025, 6:26330040251330316. doi: 10.1177/26330040251330316.
9. Ini' C, Foti PV, Farina R, Tiralongo F, Castiglione DG, Cannarozzo M, Spatola C, David E, Palmucci S, Russo A, Broggi G, Avitabile T, Basile A. Percutaneous Locoregional Therapies for the Treatment of Liver Metastases from Uveal Melanoma: A Systematic Review. Technol Cancer Res Treat. 2025;24:15330338251343144. doi: 10.1177/15330338251343144.
10. Ferraro, E.; Amaduri, A.; Ini’, C.; Travali, M.; Tiralongo, F.; Foti, P.V.; Cristaudo, C.; Basile, A. Multimodality Imaging of Moyamoya Disease: A Practical Guide for Neuroradiologists Based on a Case Report. Reports 2025, 8, 232, https://doi.org/10.3390/reports8040232.
11. Foti PV, Scavone C, Farina R, Inì C, Tiralongo F, Castiglione D, Cosentino F, Lo Greco MC, Palmucci S, Spatola C, David E, Broggi G, Salzano S, Caltabiano R, Caputo G, Ascanio S, Russo A, Fallico M, Longo A, Basile A. Ocular adnexal lymphomas: A comprehensive review with emphasis on histopathologic and magnetic resonance imaging appearance. Histol Histopathol. 2025,12:25014. doi: 10.14670/HH-25-013.
12. Erika Saccullo, Angelo Ferlazzo, Virginia Fuochi, Salvatore Furnari, Rosamaria Lombardo, Luca Spitaleri, Gianfranco Sfuncia, Giuseppe Nicotra, Pio Maria Furneri, Antonino Gulino, Rosario Pignatello, Antonio Rescifina, Vincenzo Patamia, Giuseppe Floresta. Halloysite-based multifunctional filler for antibacterial and anticorrosive protective coatings: a sustainable approach using kojic acid and ionic liquids. Surfaces and Interfaces, 2025, 77, 108023.
13. Santonocito D, Greco G, Sarpietro MG, Schoubben A, Sciacca C, Romeo G, Mangano K, Puglia C. Diroximel Fumarate-Loaded Solid Lipid Nanoparticles (DRF-SLNs) as Potential Carriers for the Treatment of Multiple Sclerosis: Preformulation Study. International Journal of Molecular Sciences. 2025; 26(24):11827. https://doi.org/10.3390/ijms262411827

B. Partecipazione in occasione di congressi scientifici nazionali ed internazionali, nell’anno 2025 e riportanti il Centro NANOMED come afferenza di uno o più autori:

Poster:

1. Debora Santonocito, Maria Grazia Sarpietro, Giuliana Greco, Aurelie Schoubben, Lucia Montenegro, Carmelo Puglia. Spanlastics: Novel Nanovesicular Carriers for Drug Delivery. 5th Conference on Innovation in Drug Delivery. Turin, 1-3 October 2025.
2. Debora Santonocito, Lucia Montenegro, Simone Ronsisvalle, Salvatore Petralia, Edy Angela Siciliano, Emanuele Amata, Annamaria Panico, Carmelo Puglia. Dynamic olfactometry: a versatile platform for environmental, cosmetic and food applications. Workshop “Novel Approaches For Skin Health”, Ferrara, 10 June 2025.
3. Salamone S, Musumeci T, Manin S, Carbone C, Cimino C, Bonaccorso A, Pignatello R. Design of Experiment approach for the development of 7,8-Dihydroxyflavone loaded ε-poly-L-lysine-lecithin nanocapsules: a systematic optimization strategy. Pharmaday 2025 | Catania 7 – 8 May 2025.
4. Manin S, Salamone S, Zingale E, Musumeci T, Carbone C, Bonaccorso A, Pignatello R. Quality by Design approach to obtain freeze-dried isoliquiritigenin nanocrystals. Pharmaday 2025 | Catania 7 – 8 May 2025.
5. Salamone S, Manin S, Cimino C, Bonaccorso A, Carbone C, Musumeci T, Pignatello R. Quality by Design approach for the development of ε-poly-L-lysine-lecithin nanocapsules for intranasal administration. CRS Italy Local Chapter Workshop 2025 | Bari 15 – 17 May 2025.
6. Manin S, Salamone S, Zingale E, Musumeci T, Carbone C, Bonaccorso A, Pignatello R. Optimization and characterization of freeze-dried nano-isoliquiritigenin by Quality by Design to increase storage stability. CRS Italy Local Chapter Workshop 2025 | Bari 15 – 17 May 2025.
7. Manin S, Musumeci T, Carbone C, Bonaccorso A, Pignatello R. Design of Experiment approach to prepare isoliquiritigenin nanocrystals: optimization and physico-chemical characterization. Nanomed Europe 2025 | Barcellona, 27 – 30 May 2025.
8. Salamone S, Musumeci T, Carbone C, Cimino C, Pignatello R. Design and characterization of ε-poly-l-lysine/lecithin nanocapsules for intranasal delivery of 7,8-dihydroxyflavone”. 2nd SITELF National PhD Summer School – XXIV ADRITELF National PhD School| Palermo 2 – 4 September 2025.
9. Manin S, Musumeci T, Zingale E, Bonaccorso A, Pellitteri R, Angeloni C, Pignatello R. From nature to nanoformulation: development of stable freeze-dried nano-isoliquiritigenin via QbD approach for N2B administration. 2nd SITELF National PhD summer school 2025| Palermo, 2-4 September 2025.
10. Manin S, Salamone S, Musumeci T, Pignatello R. Intranasal administration of nanomedicine to improve brain targeting in metabolic syndrome. 5th Conference on Innovation in Drug Delivery | Turin 1 – 3 October 2025.
11. Cimino C, Bonaccorso A, Carbone C, Pignatello R. Comparison between different manufacturing processes to produce nanostructured lipid carriers for nose-to-brain administration. 5th Conference on Innovation in Drug Delivery | Turin 1 – 3 October 2025.
12. Zingale E, Pastorello M, Marino A, Pepe G. and Pignatello R. Development of teicoplanin loaded self-nanoemulsifying drug delivery system (SNEDDS) for bacterial keratitis. 5th Conference on Innovation in Drug Delivery | Turin 1 – 3 October 2025.
13. Bonaccorso A, Zingale E, Muratori L, Fregnan F, Musumeci T, Raimondo S, Pignatello R. Design of binary nanomicelles for the sustained release of sildenafil and rolipram for potential application in peripheral nerve regeneration. 5th Conference on Innovation in Drug Delivery | Turin 1 – 3 October 2025.

Comunicazioni orali:

1. R. Pignatello. Recenti approcci nanotecnologici per il trattamento delle infezioni oculari. Congresso nazionale della nuova società italiana di microbiologia farmaceutica ETS. XV incontro della Microbiologia Farmaceutica | Messina, 13-14 Giugno 2025.
2. Manin S, Musumeci T, Carbone C, Bonaccorso A, Pignatello R. Nanocrystals technology to enhance limitations of isoliquiritigenin. Amyc Biomed 2025 | Palermo 23-25 June 2025.
3. Elide Zingale and Rosario Pignatello. Self-nanoemulsifying drug delivery systems (SNEDDS) improve curcumin’s impact on retinal protection. Amyc Biomed 2025 | Palermo 23-25 June 2025.
4. Claudia Carbone. Presentazione del Centro di Ricerca in Nanomedicina e Nanotecnologie Farmaceutiche - NANOMED. Pharmaday 2025 | Catania 7 – 8 May 2025.