Filippo Torrisi
Tell us about yourself: what is your educational and academic background?
My name is Filippo Torrisi. I hold a degree in Biology and have been working as a fixed-term researcher (type B) of Physiology at the Department of Pharmaceutical and Health Sciences since March 1, 2023. I earned my degree in Biology from the University of Catania and completed the Master’s in Experimental and Applied Biology at the University of Pavia. I later obtained a PhD in Biotechnology (XXXIII cycle), during which I spent 6 months as a visiting PhD student at the Cyceron biomedical imaging research center – Research Unit “Imagery and Therapeutic Strategies of Cerebral and Tumor Pathologies” in Caen, France.
Following my PhD, I pursued a second-level Master’s degree in “Molecular and Translational Imaging: from Preclinical to Clinical Research” at the University of Catania. I continued my academic journey with a research grant in the disciplinary sector BIO/09 – Physiology at the Department of Biomedical and Biotechnological Sciences, University of Catania. The project, titled “Preclinical GBM Investigation: Brain Microenvironmental Physiopathology and New Therapeutic Approaches,” focused on glioblastoma research.
In 2022, I was awarded a grant from the Umberto Veronesi Foundation for the project “Immune Escape and Radioresistance in Proton Boron Capture Therapy Approach for Glioblastoma.” Before my current position, I served as a fixed-term university researcher (type A) of Physiology at Kore University of Enna.
Can you briefly introduce your research?
My research focuses on the cellular and molecular responses to radiotherapy and the off-target effects that contribute to radioresistance. These effects are supported by complex communication mechanisms and interactions between tumor cells and the surrounding stromal components. A central focus of my work is the glioblastoma tumor microenvironment, which is known for its high degree of crosstalk between malignant cells and their niche, promoting tumor progression.
Additionally, my research involves in vivo models and the development of radiopharmaceuticals for diagnostic and theranostic applications. I also study the biodistribution of specific biomarkers under different pathophysiological conditions.
What are the most challenging features of your work?
Research itself is inherently challenging. It must be approached not just as a profession, but as a mission. In translational medicine, the main challenge is to contribute meaningful knowledge to the scientific community by investigating little-known molecular and cellular mechanisms that may pave the way for novel therapeutic strategies. Another significant challenge lies in the transmission of knowledge. A researcher is a lifelong learner but must also serve as a mentor to students. Striking a balance between continuing to study and teaching others is both demanding and deeply rewarding.
What are the most 'intriguous' and fulfilling aspects of your research?
The most intriguing, and at times most complex, aspect of research is that a hypothesis can either be confirmed or disproven. However, disproving a hypothesis is not a failure; it often opens up new perspectives and leads to unexpected discoveries.
On a more tangible level, one of the most fulfilling moments is when your efforts culminate in a publication and your work becomes part of the scientific dialogue. Equally rewarding is earning the respect and appreciation of your students and colleagues.
THAT’S ME in few words! What are your outside hobbies?
Give me the sea at 7 in the morning or 8 in the evening, that’s me. A walk, a jog, a swim, and complete relaxation. That doesn’t mean I’m a loner, I enjoy good company, but I also find great value in the small, simple pleasures of life. For me, sport is pure fun. I love spending quality time with my family and sharing joyful moments with them.